Results 61 to 70 of about 15,292 (254)

Gap Junctions or Hemichannel-Dependent and Independent Roles of Connexins in Fibrosis, Epithelial–Mesenchymal Transitions, and Wound Healing

Biomolecules, 2023
Fibrosis initially appears as a normal response to damage, where activated fibroblasts produce large amounts of the extracellular matrix (ECM) during the wound healing process to assist in the repair of injured tissue. However, the excessive accumulation
Yuting Li, Francisca M. Acosta, Jean X. Jiang   +2 more
doaj   +1 more source

Astroglial Hemichannels and Pannexons: The Hidden Link between Maternal Inflammation and Neurological Disorders

International Journal of Molecular Sciences, 2021
Maternal inflammation during pregnancy causes later-in-life alterations of the offspring’s brain structure and function. These abnormalities increase the risk of developing several psychiatric and neurological disorders, including schizophrenia ...
Juan Prieto-Villalobos, Tanhia F. Alvear, A. Liberona, C. Lucero, Claudio J. Martinez-Araya, Javiera Balmazabal, Carla A Inostroza, Gigliola Ramírez, Gonzalo I. Gómez, J. Orellana   +9 more
semanticscholar   +1 more source

Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice. [PDF]

PLoS ONE, 2013
Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation.
Pablo J Sáez, Juan A Orellana, Natalia Vega-Riveros, Vania A Figueroa, Diego E Hernández, Juan F Castro, Andrés D Klein, Jean X Jiang, Silvana Zanlungo, Juan C Sáez   +9 more
doaj   +1 more source

Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids

Science Advances, 2020
Cryo-EM structures of the undocked INX-6 hemichannels reveal a pore obstruction and N-terminal rearrangement in lipids. Gap junctions form intercellular conduits with a large pore size whose closed and open states regulate communication between adjacent ...
B. Burendei, R. Shinozaki, Masakatsu Watanabe, T. Terada, K. Tani, Y. Fujiyoshi, A. Oshima   +6 more
semanticscholar   +1 more source

Connexins : substrates and regulators of autophagy [PDF]

, 2016
Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert, D'hondt, Catheleyne, Decuypere, Jean-Paul, Iyyathurai, Jegan, Leybaert, Luc   +4 more
core   +1 more source

The connexin mimetic peptide Gap27 and Cx43-Knockdown reveal differential roles for Connexin43 in wound closure events in skin model systems [PDF]

, 2018
In the epidermis, remodelling of Connexin43 is a key event in wound closure. However, controversy between the role of connexin channel and non-channel functions exist.
Annette Graham, Chrysovalantou Faniku, Claire Lorraine, Erin O’Shaughnessy, Oviedo-Orta, Patricia Martin, Scott R. Johnstone, Sebastian Greenhough   +7 more
core   +9 more sources

Connexin 43 Channels in Osteocytes Regulate Bone Responses to Mechanical Unloading

Frontiers in Physiology, 2020
Connexin (Cx) 43 forms gap junctions and hemichannels that mediate communication between osteocytes and adjacent cells or the extracellular environment in bone, respectively.
Dezhi Zhao, Ruofei Liu, Guobin Li, Meng Chen, Peng Shang, Hui Yang, Hui Yang, Jean X. Jiang, Huiyun Xu, Huiyun Xu, Huiyun Xu   +10 more
doaj   +1 more source

Upregulation of Sarcolemmal Hemichannels and Inflammatory Transcripts with Neuromuscular Junction Instability during Lower Limb Unloading in Humans

Biology, 2023
Human skeletal muscle atrophy and a disproportionate force loss occur within a few days of unloading in space and on Earth, but the underlying mechanisms are not fully understood.
Giuseppe Sirago, Julián Candia, Martino V. Franchi, Fabio Sarto, Elena Monti, Luana Toniolo, Carlo Reggiani, Emiliana Giacomello, Sandra Zampieri, Lisa M. Hartnell, Giuseppe De Vito, Marco Sandri, Luigi Ferrucci, Marco V. Narici   +13 more
doaj   +1 more source

Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes [PDF]

, 2017
Identifying mechanisms by which cells of the osteoblastic lineage communicate in vivo is complicated by the mineralised matrix that encases osteocytes, and thus, vital mechanoadaptive processes used to achieve load‐bearing integrity remain unresolved. We
Aarden, Ajubi, Alford, Bancroft, Batra, Bonewald, Brighton, Bruzzone, Burger, Burger, Burger, Chan, Cheng, Cheng, Cheng, Cheng, Cherian, Cherian, Chiba, Civitelli, Dallas, Damien, Damien, Davidson, Dietrich, Donahue, Doty, Endres, Frost, Genetos, Gluhak-Heinrich, Goldberg, Hasegawa, Heino, Iqbal, Irie, Javaheri, Javaheri, Jiang, Jones, Kamioka, Kato, Kleinnulend, Kulkarni, Lanyon, Nijweide, Osborne, Palumbo, Pitsillides, Rawlinson, Rawlinson, Rawlinson, Rawlinson, Rawlinson, Ren, Schirrmacher, Schwab, Shapiro, Siller-Jackson, Skerry, Skerry, Stanford, Su, Sugawara, Tan, Tanaka, Tanaka-Kamioka, Tatsumi, Taylor, Ulmann, Uzer, Van der Plas, Vazquez, Vezeridis, Weinbaum, Westbroek, Yamaguchi, Yang, Yellowley, You, Zaman, Zaman, Zhao, Ziambaras   +83 more
core   +3 more sources

Connexin Hemichannels in Astrocytes: Role in CNS Disorders

Frontiers in Molecular Neuroscience, 2019
In the central nervous system (CNS), astrocytes form networks interconnected by gap junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an adjoining hemichannel, astrocytic connexins can act as hemichannels to control the ...
Lingyan Xing, Tuo Yang, Shusen Cui, Gang Chen   +3 more
semanticscholar   +1 more source