Results 81 to 90 of about 15,292 (254)

Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels

Journal of Cell Biology, 2020
Khalil et al. show that breast cancer cells release purines into the extracellular space via connexin-43 hemichannels. Extracellular purines activate adenosine receptors and the AKT pathway to induce and maintain leader cell function and collective ...
Antoine A. Khalil, Olga V. Ilina, A. Vasaturo, Jan-Hendrik Venhuizen, Manon Vullings, Victor Venhuizen, A. Bilos, C. Figdor, P. Span, P. Friedl   +9 more
semanticscholar   +1 more source

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source

Connexin hemichannels: novel mediators of toxicity [PDF]

Archives of Toxicology, 2014
Tissue homeostasis is driven by a myriad of extracellular, intracellular and intercellular signaling networks. Direct communication between neighboring cells is typically controlled by gap junctions (Decrock et al. 2009; Nielsen et al. 2012; Vinken et al. 2011).
openaire   +3 more sources

Supporting Cells and Their Potential Roles in Cisplatin-Induced Ototoxicity

Frontiers in Neuroscience, 2022
Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss. Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation, a proinflammatory environment and the generation of reactive oxygen species ...
Sofia Waissbluth, Juan Cristóbal Maass, Helmuth A. Sanchez, Agustín D. Martínez   +3 more
doaj   +1 more source

TNF-α Plus IL-1β Induces Opposite Regulation of Cx43 Hemichannels and Gap Junctions in Mesangial Cells through a RhoA/ROCK-Dependent Pathway

International Journal of Molecular Sciences, 2021
Connexin 43 (Cx43) is expressed in kidney tissue where it forms hemichannels and gap junction channels. However, the possible functional relationship between these membrane channels and their role in damaged renal cells remains unknown. Here, analysis of
Claudia M. Lucero, Lucas Marambio-Ruiz, Javiera Balmazabal, Juan Prieto-Villalobos, Marcelo León, P. Fernández, J. Orellana, V. Velarde, J. Sáez, Gonzalo I. Gómez   +9 more
semanticscholar   +1 more source

Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity? [PDF]

, 2017
Indexación: Scopus.In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons.
Alcayaga, J., Retamal, M.A., Riquelme, M.A., Stehberg, J.   +3 more
core   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice

EBioMedicine, 2020
Background Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as “leaky” hemichannels.
Y. Kuang, Veronica Zorzi, D. Buratto, G. Ziraldo, F. Mazzarda, Chiara Peres, C. Nardin, A. Salvatore, Francesco Chiani, F. Scavizzi, M. Raspa, Min Qiang, Youjun Chu, Xiaojie Shi, Yu Li, Lili Liu, Yaru Shi, F. Zonta, Guang Yang, R. Lerner, F. Mammano   +20 more
semanticscholar   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

Connexons and pannexons: newcomers in neurophysiology

Frontiers in Cellular Neuroscience, 2014
Connexin hemichannels are single membrane channels which have been traditionally thought to work in pairs to form gap junction channels across two opposing cells.
Giselle eCheung, Oana eChever, Nathalie eRouach   +2 more
doaj   +1 more source