Results 81 to 90 of about 6,538 (174)
Dye-uptake Experiment through Connexin Hemichannels
Bio-Protocol, 2014 Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
doaj +1 more source
Cancer Science, Volume 117, Issue 5, Page 1333-1345, May 2026.Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda +2 more
wiley +1 more source
Motifs in the permeation pathway of connexin channels mediate Ca2+ and voltage sensing.
Frontiers in Physiology, 2014 Connexin channels mediate electrical coupling, intercellular molecular signaling and extracellular release of signaling molecules. Connexin proteins assemble intracellularly as hexamers to form plasma membrane hemichannels.
Andrew L. Harris, Jorge E. Contreras
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Antidepressants impact connexin 43 channel functions in astrocytes
Frontiers in Cellular Neuroscience, 2016 Glial cells, and in particular astrocytes, are crucial to maintain neuronal microenvironment by regulating energy metabolism, neurotransmitter uptake, gliotransmission and synaptic development.
Tiffany eJeanson +6 more
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Frontiers in Cellular Neuroscience, 2018 Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca2+ transients, which are sensitive to purinergic receptor ...
Mario Wellmann +8 more
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Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease
Frontiers in Cellular Neuroscience, 2019 Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper ...
Sebastián Vejar +7 more
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Restraint stress increases hemichannel activity in hippocampal glial cells and neurons
Frontiers in Cellular Neuroscience, 2015 Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression.
Juan Andrés Orellana +6 more
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Cyclic nucleotide permeability through unopposed connexin hemichannels
Frontiers in Pharmacology, 2013 Cyclic AMP is a well-known intracellular and intercellular second messenger. The membrane permeability of such molecules has potential importance for autocrine like or paracrine-like delivery.
Virginijus eValiunas
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Connexin43 Hemichannel-Mediated Regulation of Connexin43
PLoS ONE, 2013 Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we ...
Kai Li +7 more
openaire +4 more sources
Nanomechanics of Hemichannel Conformations [PDF]
Journal of Biological Chemistry, 2006 Fei Liu +3 more
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