Results 101 to 110 of about 15,292 (254)
Connexin 43 plays a role in pulmonary vascular reactivity in mice [PDF]
, 2018 Pulmonary arterial hypertension (PAH) is a chronic condition characterized by vascular remodeling and increased vaso-reactivity. PAH is more common in females than in males (~3:1).
Andrew Shaw +11 more
core +1 more source
Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo
Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.ABSTRACT The local response of the bladder wall to stretch is believed to result from the coordinated activation of mechanosensitive ion channels located in the plasma membrane of the cells that form the wall's urothelial and detrusor smooth muscle (DSM) layers.
Igor B. Philyppov +4 more
wiley +1 more source
Innexins: Expression, Regulation, and Functions
Frontiers in Physiology, 2018 The innexin (Inx) proteins form gap junction channels and non-junctional channels (named hemichannels) in invertebrates. These channels participate in cellular communication playing a relevant role in several physiological processes.
Juan Güiza +4 more
doaj +1 more source
Connexins in Cancer: Jekyll or Hyde?
Biomolecules, 2020 The expression, localization, and function of connexins, the protein subunits that comprise gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap junction channels, connexins also form hemichannels that allow ...
Erin E. Mulkearns-Hubert +2 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Electrical synaptic transmission is an essential form of interneuronal communication which is mediated by gap junctions that permit ion flow. Three gene families (connexins, innexins, and pannexins) have evolved to form gap junctional channels.
Qiqian Wang, Shenquan Liu
doaj +1 more source
Cx43 and mechanotransduction in bone [PDF]
, 2015 Bone adaptation to changes in mechanical stimuli occurs by adjusting bone formation and resorption by osteoblasts and osteoclasts, to maintain optimal bone mass.
Donahue, Henry J. +2 more
core +1 more source
Diabetic Medicine, Volume 43, Issue 4, April 2026.Abstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
J. K. Ward +4 more
wiley +1 more source
Nature of plasmalemmal functional “hemichannels”
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012 The molecular identity of the protein forming "hemichannels" at non-junctional membranes is disputed. The family of gap junction proteins, innexins, connexins, and pannexins share several common features, including permeability characteristics and sensitivity to blocking agents.
openaire +2 more sources
Biomolecules, 2020 Barrier function is a vital homeostatic mechanism employed by epithelial and endothelial tissue. Diseases across a wide range of tissue types involve dynamic changes in transcellular junctional complexes and the actin cytoskeleton in the regulation of ...
Randy E. Strauss, Robert G. Gourdie
doaj +1 more source
Cardiac Connexin-43 Hemichannels and Pannexin1 Channels: Provocative Antiarrhythmic Targets
International Journal of Molecular Sciences, 2020 Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal caveolae/rafts compartments. GJCs are fundamental for the direct cardiac cell-to-cell
K. Andelova +7 more
semanticscholar +1 more source