Results 101 to 110 of about 8,652 (209)
Calcium binding and voltage gating in Cx46 hemichannels
, 2017 The opening of connexin (Cx) hemichannels in the membrane is tightly regulated by calcium (Ca2+) and membrane voltage. Electrophysiological and atomic force microscopy experiments indicate that Ca2+ stabilizes the hemichannel closed state.
Bernardo I. Pinto +6 more
core +1 more source
Correlative Studies of Gating in Cx46 and Cx50 Hemichannels and Gap Junction Channels [PDF]
, 2005 Transjunctional voltage (Vj) gating of gap junction (GJ) channels formed of connexins has been proposed to occur by gating of the component hemichannels.
Kronengold, Jack +4 more
core +1 more source
Motifs in the permeation pathway of connexin channels mediate Ca2+ and voltage sensing.
Frontiers in Physiology, 2014 Connexin channels mediate electrical coupling, intercellular molecular signaling and extracellular release of signaling molecules. Connexin proteins assemble intracellularly as hexamers to form plasma membrane hemichannels.
Andrew L. Harris, Jorge E. Contreras
doaj +1 more source
Measurement of Ca2+ Uptake Through Connexin Hemichannels
Increasing evidence points to deregulated flux of ionized calcium (Ca2+) mediated by hyperactive mutant connexin (Cx) hemichannels (HCs) as a common gain-of-function etiopathogenetic mechanism for several diseases, ranging from skin disorders to nervous ...
Nardin C., Mammano F.
core +1 more source
Air-Stimulated ATP Release from Keratinocytes Occurs through Connexin Hemichannels [PDF]
, 2013 Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis.
Albrecht, Phillip J. +11 more
core +2 more sources
Endothelial connexin hemichannels as a novel endothelial regulatory mechanism of vasodilation
, 2022 © FASEB.The vascular endothelium regulates vasomotor tone in arterioles through intercellular conduction of electrical signals by gap junctions. Endothelial vasodilation is mediated by nitric oxide (NO) and by a hyperpolarizing current initiated in the ...
Burboa P.C. +5 more
core +1 more source
Antidepressants impact connexin 43 channel functions in astrocytes
Frontiers in Cellular Neuroscience, 2016 Glial cells, and in particular astrocytes, are crucial to maintain neuronal microenvironment by regulating energy metabolism, neurotransmitter uptake, gliotransmission and synaptic development.
Tiffany eJeanson +6 more
doaj +1 more source
ATP and mechanisms of central CO2 chemosensitivity [PDF]
ATP release from the surface of the ventro-lateral medulla (VLM) is integral to the hypercapnic response in vivo and can be seen in vitro. By employing horizontal slices of the ventral medulla containing the ventral chemosensitive nuclei, I have ...
Huckstepp, Robert T. R.
core
Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword [PDF]
, 2018 The classical view of synapses as the functional contact between presynaptic and postsynaptic neurons has been challenged in recent years by the emerging regulatory role of glial cells.
Del Río, Rodrigo +10 more
core +1 more source
Frontiers in Cellular Neuroscience, 2018 Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca2+ transients, which are sensitive to purinergic receptor ...
Mario Wellmann +8 more
doaj +1 more source