Results 111 to 120 of about 15,292 (254)

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet

Frontiers in Cellular Neuroscience, 2014
Nicotine, the most important neuroteratogen of tobacco smoke, can reproduce brain and cognitive disturbances per se when administered prenatally. However, it is still unknown if paracrine signaling among brain cells participates in prenatal nicotine ...
Juan Andrés Orellana, Dolores eBusso, Gigliola eRamirez, Marlys eCampos, Attilio eRigotti, Jaime eEugenin, Rommy eVon Bernhardi   +6 more
doaj   +1 more source

Connexin 43 Modulates β‐Catenin–Dependent Transcription and Secretory Responses to Oscillatory Fluid Flow in Osteocytes

Journal of Orthopaedic Research, Volume 44, Issue 3, March 2026.
ABSTRACT Osteocytes detect and transduce mechanical cues into biochemical signals that regulate bone remodeling. Connexin 43 (Cx43) is the predominant gap junction protein in osteocytes, but its role in β‐catenin signaling during mechanical loading remains unclear.
Michael A. Friedman, Yue Zhang, Nathanael Neece, Caleb Ryan, Chris Brunkhorst, Henry J. Donahue   +5 more
wiley   +1 more source

Pannexin channels are not gap junction hemichannels [PDF]

Channels, 2011
Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins, connexins. However, the functional role for the pannexin oligomers, or pannexons, is different from
Gina E, Sosinsky, Daniela, Boassa, Rolf, Dermietzel, Heather S, Duffy, Dale W, Laird, Brian, MacVicar, Christian C, Naus, Silvia, Penuela, Eliana, Scemes, David C, Spray, Roger J, Thompson, Hong-Bo, Zhao, Gerhard, Dahl   +12 more
openaire   +2 more sources

Peroxisome Proliferator‑Activated Receptor Gamma Coactivator‑1α Deficiency in Hippocampal Astrocytes Underlies Enhanced Fear Memory Retrieval in Male Posttraumatic Stress Disorder Model Mice

MedComm, Volume 7, Issue 3, March 2026.
PGC‑1α downregulation in hippocampal astrocytes disrupts ATP release and reduces connexin 43 (CX43) expression, impairing neuro‑glial communication. This promotes enhanced fear memory retrieval in PTSD. Chemogenetic activation of astrocytes or PGC‑1α agonist treatment rescues both CX43 expression and fear behavior, identifying astrocytic PGC‑1α/CX43 as
Juan Wang, Xiaoyu Chen, Daokang Chen, Shaojie Yang, Jingji Wang, Ming Chen, Guoqi Zhu   +6 more
wiley   +1 more source

Analysis of trafficking, stability and function of human connexin 26 gap junction channels with deafness-causing mutations in the fourth transmembrane helix. [PDF]

PLoS ONE, 2013
Human Connexin26 gene mutations cause hearing loss. These hereditary mutations are the leading cause of childhood deafness worldwide. Mutations in gap junction proteins (connexins) can impair intercellular communication by eliminating protein synthesis ...
Cinzia Ambrosi, Amy E Walker, Adam D Depriest, Angela C Cone, Connie Lu, John Badger, I Martha Skerrett, Gina E Sosinsky   +7 more
doaj   +1 more source

S-nitrosylation of Connexin43 hemichannels elicits cardiac stress induced arrhythmias in Duchenne Muscular Dystrophy mice.

JCI Insight, 2019
Patients with Duchene Muscular Dystrophy (DMD) commonly present severe ventricular arrhythmias that contribute to heart failure. Arrhythmias and lethality are also consistently observed in adult Dmdmdx mice, a mouse model of DMD, after acute β-adrenergic
Mauricio A. Lillo, Eric Himelman, N. Shirokova, Lai-Hua Xie, D. Fraidenraich, J. Contreras   +5 more
semanticscholar   +1 more source

Mind the gap: connexins and cell–cell communication in the diabetic kidney [PDF]

, 2015
Connexins, assembled as a hexameric connexon, form a transmembrane hemichannel that provides a conduit for paracrine signalling of small molecules and ions to regulate the activity and function of adjacent cells.
A Abed, A Awad, A Cove-Smith, A Kurtz, A Mendoza-Naranjo, A Pfenniger, A Sipos, AF Li, AF Li, BN Giepmans, C Qiu, C Wagner, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, Claire E. Hills, CM Wang, CS Wright, D Bosco, D Lu, DW Laird, E Yaoita, F Hanner, F Mumtaz, G Sahu, Gareth W. Price, GS Goldberg, GS Hillis, GS Hillis, I Loeffler, J Gilleron, J Kronengold, J Wada, J Yao, J Yao, J Yao, J Zhang, JA Haefliger, JA Haefliger, JA Wright, JC Herve, JH Zhang, K Fujimoto, K Sawai, L Gal Le, L Liu, M Dalla Vestra, M Firouzi, M Gerl, M Oppermann, M Oyamada, MA Retamal, MS Nielsen, MW Bobbie, N Defamie, N Krattinger, N Wang, P Svenningsen, Paul E. Squires, PD Lampe, Q Yan, R Hernández-Salinas, R Hirschberg, RM Mege, S Tsuchida, SP Prabhakar, SS Prabhakar, T Inoguchi, T Morioka, T Sato, T Takenaka, T Takenaka, T Tien, WM Jongen, X Xie, X Zhang, Y Liu, Y Suzaki, YC Lee   +82 more
core   +1 more source

Characterization of Nonjunctional Hemichannels in Caterpillar Cells [PDF]

Journal of Insect Science, 2011
Recent studies have demonstrated that hemichannels, which form gap junctions when paired from apposing cells, may serve additional roles when unpaired including cell adhesion and paracrine communication. Hemichannels in mammals are formed by connexins or pannexins, while in insects they are formed by pannexin homologues termed innexins.
Luo, Kaijun, Turnbull, Matthew W.
openaire   +2 more sources

Apocynin Treatment Prevents Cardiac Connexin 43 Hemichannels Hyperactivity by Reducing Nitroso-Redox Stress in Mdx Mice

International Journal of Molecular Sciences, 2020
Duchenne muscular dystrophy (DMD) is a fatal disease that causes cardiomyopathy and is associated with oxidative stress. In the heart, oxidative stress interferes with the location of connexin 43 (Cx43) to the intercalated discs causing its ...
Alejandra Z. Vielma, M. Boric, D. González   +2 more
semanticscholar   +1 more source