Results 121 to 130 of about 15,292 (254)

Current and Emerging Pharmacologic Therapies for Diabetic Retinopathy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Diabetic retinopathy, a prevalent microvascular complication of diabetes mellitus, is a leading cause of blindness among adults in developed countries. Risk factors include prolonged duration of diabetes, elevated glycosylated hemoglobin levels, hypertension, and dyslipidemia, with rapid glucose reduction also increasing risk for developing ...
Jennifer N. Clements, Julia Mesawich, Cassandra Twisdale   +2 more
wiley   +1 more source

Connexin 43 Hemichannels Are Permeable to ATP [PDF]

The Journal of Neuroscience, 2008
Astrocytes are electrically nonexcitable cells that communicate by means of Ca2+signaling. Long-distance intercellular Ca2+waves are initiated by release of ATP and activation of purinergic receptors on nearby cells. Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof that ATP exits through Cx43 hemichannels does ...
Jian, Kang, Ning, Kang, Ditte, Lovatt, Arnulfo, Torres, Zhuo, Zhao, Jane, Lin, Maiken, Nedergaard   +6 more
openaire   +2 more sources

Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species

International Journal of Molecular Sciences, 2020
Recent studies indicate that connexin hemichannels do not act as freely permeable non-selective pores, but they select permeants in an isoform-specific manner with cooperative, competitive and saturable kinetics.
J. Sáez, Aníbal A Vargas, Diego E. Hernández, F. Ortiz, C. Giaume, J. Orellana   +5 more
semanticscholar   +1 more source

Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress Vulnerability

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Low/brief glucocorticoid (GC) elevations can enhance mitochondrial output (↑ oxygen consumption rate, OCR; ↑ mitochondrial membrane potential, ΔΨm) and Ca2+ buffering, in part via glucocorticoid receptor (GR) trafficking to mitochondria in complexes with Bcl2 and Bag1.
Paweł Hanus, Dorota Frydecka, Michał Ślęzak   +2 more
wiley   +1 more source

Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression

Biological Research
Background Spreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neurons and glial cells.
Juan E. Tichauer, Matías Lira, Waldo Cerpa, Juan A. Orellana, Juan C. Sáez, Maximiliano Rovegno   +5 more
doaj   +1 more source

Neuronal involvement in muscular atrophy

Frontiers in Cellular Neuroscience, 2014
The innervation of skeletal myofibers exerts a crucial influence on the maintenance of muscle tone and normal operation. Consequently, denervated myofibers manifest atrophy, which is preceded by an increase in sarcolemma permeability.
Bruno Alejandro Cisterna, Christopher eCardozo, Christopher eCardozo, Juan C Saez, Juan C Saez   +4 more
doaj   +1 more source

Connexins and pannexins in the skeleton: gap junctions, hemichannels and more [PDF]

, 2015
Regulation of bone homeostasis depends on the concerted actions of bone-forming osteoblasts and bone-resorbing osteoclasts, controlled by osteocytes, cells derived from osteoblasts surrounded by bone matrix.
Plotkin, Lilian I., Stains, Joseph P.
core   +1 more source

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

Glia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean J. Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed Hassan Farah, Jeffrey D. Rothstein   +9 more
wiley   +1 more source

Dye-uptake Experiment through Connexin Hemichannels

Bio-Protocol, 2014
Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
doaj   +1 more source

Gap junctional and ephaptic coupling in cardiac electrical propagation: homocellular and heterocellular perspectives

The Journal of Physiology, Volume 604, Issue 4, Page 1592-1606, 15 February 2026.
Abstract figure legend Intricate cellular electrical coupling networks in the heart. Various cell types couple the central cardiomyocyte through gap junctional contacts, with the exception of neurons. Whether ephaptic coupling (EpC) occurs in homocellular or heterocellular contexts beyond cardiomyocyte–cardiomyocyte interactions remains unclear ...
Xiaobo Wu, Laura Beth Payne, Robert G. Gourdie   +2 more
wiley   +1 more source