Results 141 to 150 of about 15,292 (254)

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke [PDF]

, 2019
Connexin43 (Cx43) function is influenced by kinases that phosphorylate specific serine sites located near its C-terminus. Stroke is a powerful inducer of kinase activity, but its effect on Cx43 is unknown. We investigated the impact of wild-type (WT) and
Bechberger, John F, De Bock, Marijke, Freitas-Andrade, Moises, Lampe, Paul D, Leybaert, Luc, Naus, Christian C, Wang, Nan   +6 more
core   +2 more sources

Electrophysiology of Single and Aggregate Cx43 Hemichannels

PLoS ONE, 2012
Connexin43 (Cx43) is the most ubiquitous gap junction protein in the human body and is essential for cell-to-cell communication in a variety of organs and organ systems. As a result, Cx43 is responsible for mediating both electrical and chemical signals, passing dissolved solutes and small signaling molecules between cells in a coordinated fashion ...
Cole Brokamp, Jacob Todd, Carlo Montemagno, David Wendell   +3 more
openaire   +3 more sources

Astroglial Ca2+-Dependent Hyperexcitability Requires P2Y1 Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy

Frontiers in Cellular Neuroscience, 2018
Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca2+ transients, which are sensitive to purinergic receptor ...
Mario Wellmann, Mario Wellmann, Carla Álvarez-Ferradas, Carla Álvarez-Ferradas, Carola J. Maturana, Carola J. Maturana, Juan C. Sáez, Juan C. Sáez, Christian Bonansco   +8 more
doaj   +1 more source

Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease

Frontiers in Cellular Neuroscience, 2019
Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper ...
Sebastián Vejar, Juan E. Oyarzún, Juan E. Oyarzún, Mauricio A. Retamal, Mauricio A. Retamal, Fernando C. Ortiz, Juan A. Orellana, Juan A. Orellana   +7 more
doaj   +1 more source

Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity [PDF]

, 2018
The precise contribution of astrocytes in neuroinflammatory process occurring in Parkinson's disease (PD) is not well characterized. In this study, using GR(Cx30CreERT2) mice that are conditionally inactivated for glucocorticoid receptor (GR) in ...
A Dey, A Klegeris, A Koulakoff, A Nimmerjahn, Anne-Claire Compagnion, Annette Koulakoff, AR Clark, B Mirza, C Giaume, C Giaume, C Giaume, C Schnell, Chenju Yi, Christian Giaume, CK Glass, CK Liao, CL Jones, EC Hirsch, EC Hirsch, Etienne C. Hirsch, F Ros-Bernal, F Tronche, Frank W Pfrieger, François Tronche, G Charron, GG Kovacs, H Braak, H Hirase, J Miklossy, J Waak, K Bosscher De, K Saijo, K Sathe, K Wakabayashi, L Leybaert, Layal Maatouk, LM Chow, Luc Leybaert, M Bock De, M Bock De, M Slezak, MA Carrillo-de Sauvage, MA Retamal, Maria-Angeles Carrillo-de Sauvage, MD Muzumdar, MV Sofroniew, N Esen, N Wang, N Wang, P Damier, Pascal Ezan, PJ Barnes, PL McGeer, R Newton, S Vyas, SA Schneider, Sheela Vyas, Stéphane Hunot, V Abudara, V Abudara, W Liu, Y Chinenov, Y Ouchi, YJ Song   +63 more
core   +4 more sources

Cyclic nucleotide permeability through unopposed connexin hemichannels

Frontiers in Pharmacology, 2013
Cyclic AMP is a well-known intracellular and intercellular second messenger. The membrane permeability of such molecules has potential importance for autocrine like or paracrine-like delivery.
Virginijus eValiunas
doaj   +1 more source

The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring

Frontiers in Cellular Neuroscience, 2019
Clinical evidence has revealed that children born from mothers exposed to viral and bacterial pathogens during pregnancy are more likely to suffer various neurological disorders including schizophrenia, autism bipolar disorder, major depression, epilepsy,
C. Chávez, J. E. Oyarzún, B. C. Avendaño, Luis A. Mellado, Carla A Inostroza, Tanhia F. Alvear, J. Orellana   +6 more
semanticscholar   +1 more source

Posttranslational Modifications in Connexins and Pannexins [PDF]

, 2018
Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring ...
Billaud, Marie, Isakson, Brant, Johnstone, Scott, Lohman, Alexander, Taddeo, Evan   +4 more
core  

Conductive and Kinetic Properties of Connexin45 Hemichannels Expressed in Transfected HeLa Cells [PDF]

, 2018
Human HeLa cells transfected with mouse connexin Cx45 were used to examine the conductive and kinetic properties of Cx45 hemichannels. The experiments were carried out on single cells using a voltage-clamp method.
Bader, P., Weingart, R.
core  

Efecto de la activación adrenérgica insular en la neofobia gustatoria [PDF]

, 2016
Tesis (Magíster en Biotecnología)Este proyecto ha sido financiado por el Proyecto Fondecyt nº 1130724.La respuesta frente al estrés corresponde a la capacidad de un organismo de responder frente a un estímulo estresante y volver a su homeostasis.
Rojas Silva, Sebastián Andrés
core