Results 41 to 50 of about 6,486 (158)
Induction of Connexin-hemichannel Opening
Bio-Protocol, 2014 Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
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Connexin 43 Channels in Osteocytes Regulate Bone Responses to Mechanical Unloading
Frontiers in Physiology, 2020 Connexin (Cx) 43 forms gap junctions and hemichannels that mediate communication between osteocytes and adjacent cells or the extracellular environment in bone, respectively.
Dezhi Zhao +10 more
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Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death. [PDF]
PLoS ONE, 2012 Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive.
Jingwei Chi +7 more
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Biology, 2023 Human skeletal muscle atrophy and a disproportionate force loss occur within a few days of unloading in space and on Earth, but the underlying mechanisms are not fully understood.
Giuseppe Sirago +13 more
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Connexin 43 Hemichannels Are Permeable to ATP [PDF]
The Journal of Neuroscience, 2008 Astrocytes are electrically nonexcitable cells that communicate by means of Ca2+signaling. Long-distance intercellular Ca2+waves are initiated by release of ATP and activation of purinergic receptors on nearby cells. Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof that ATP exits through Cx43 hemichannels does ...
Jian, Kang +6 more
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Redox Biology, 2016 Connexin (Cx) hemichannels regulate many cellular processes with little information available regarding their mechanisms. Given that many pathological factors that activate hemichannels also disrupts the integrity of cellular junctions, we speculated a ...
Yuan Chi +6 more
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Pannexin channels are not gap junction hemichannels [PDF]
Channels, 2011 Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins, connexins. However, the functional role for the pannexin oligomers, or pannexons, is different from
Gina E, Sosinsky +12 more
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Characterization of Nonjunctional Hemichannels in Caterpillar Cells [PDF]
Journal of Insect Science, 2011 Recent studies have demonstrated that hemichannels, which form gap junctions when paired from apposing cells, may serve additional roles when unpaired including cell adhesion and paracrine communication. Hemichannels in mammals are formed by connexins or pannexins, while in insects they are formed by pannexin homologues termed innexins.
Luo, Kaijun, Turnbull, Matthew W.
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Detecting CO2-Sensitive Hemichannels in Neurons in Acute Brain Slices
STAR Protocols, 2020 Summary: This protocol provides two independent methods to functionally detect the neuronal expression of CO2-sensitive hemichannels. These hemichannels (consisting of connexins 26 or 30) are directly gated by CO2, independent of pH changes and until ...
Emily Hill, Nicholas Dale, Mark J. Wall
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Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases
Frontiers in Physiology, 2014 In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez +3 more
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