Results 21 to 30 of about 8,652 (209)
Pannexin channels are not gap junction hemichannels [PDF]
Channels, 2011 Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins, and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins,
Dahl, Gerhard +25 more
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Electrophysiology of single and aggregate Cx43 hemichannels. [PDF]
PLoS ONE, 2012 Connexin43 (Cx43) is the most ubiquitous gap junction protein in the human body and is essential for cell-to-cell communication in a variety of organs and organ systems. As a result, Cx43 is responsible for mediating both electrical and chemical signals,
Carlo Montemagno (125840) +7 more
core +4 more sources
Cyclic nucleotide permeability through unopposed connexin hemichannels [PDF]
Frontiers in Pharmacology, 2013 Cyclic AMP is a well-known intracellular and intercellular second messenger. The membrane permeability of such molecules has potential importance for autocrine like or paracrine-like delivery.
Virginijus eValiunas
doaj +2 more sources
Hemichannels; from the molecule to the function [PDF]
Frontiers in Physiology, 2014 Coordinated cell interactions are required to accomplish several complex and dynamic tasks observed in several tissues. Cell function may be coordinated by cell-to-cell communication through gap junctions channels (GJCs). These channels are formed by the serial docking of two hemichannels, which in turn are formed by six protein subunits called ...
Retamal, M., Sáez, Juan Carlos
openaire +4 more sources
Adhesive properties of connexin hemichannels [PDF]
Glia, 2008 AbstractGap junctions are intercellular channels formed by hemichannels (or connexons) from two neighboring cells. Hemichannels, which are composed of proteins called connexins, can function as conduits of ATP and glutamate, and interact with adhesion molecules and other signaling elements.
M L, Cotrina, J H-C, Lin, M, Nedergaard
openaire +2 more sources
Frontiers in Physiology, 2014 Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly driven by the release of extracellular ATP through Cx43 hemichannels.
Catheleyne eD'hondt +4 more
doaj +1 more source
Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading
eLife, 2022 Mechanical stimulation, such as physical exercise, is essential for bone formation and health. Here, we demonstrate the critical role of osteocytic Cx43 hemichannels in anabolic function of bone in response to mechanical loading.
Dezhi Zhao +6 more
doaj +1 more source
GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN [PDF]
, 2004 The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and stroke, i.e.
Stridh, Malin +7 more
core +1 more source
Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria
Molecules, 2017 In addition to gap junctional channels that mediate cell-to-cell communication, connexins form hemichannels that are present at the plasma membrane. Since hemichannels are permeable to small hydrophilic compounds, including metabolites and signaling ...
Mariana C. Fiori +4 more
doaj +1 more source
Extracellular cysteine in connexins: role as redox sensors
Frontiers in Physiology, 2016 Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Mauricio Antonio Retamal +7 more
doaj +1 more source