Results 21 to 30 of about 15,292 (254)
Chemosphere, 2023 Microplastics (MPs) and cadmium (Cd) are important environmental pollutants, that damage the liver. However, the effect and mechanism of combined Cd and MPs exposure on liver fibrosis are still largely unknown.
Jian Sun +10 more
semanticscholar +1 more source
Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias
The Journal of General Physiology, 2023 This work demonstrates that the opening of lateralize cardiac connexin-43 hemichannels, in the absence of a cardiac pathology, is still sufficient to alter cardiac membrane excitability and promote arrhythmias upon β-adrenergic cardiac stress.
Mauricio A. Lillo +9 more
semanticscholar +1 more source
Cell Communication and Signaling, 2023 Background Without a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates disease severity and is contributed to by multiple cell types.
E. Roger +8 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Although symptomatic medications are available, many temporal lobe epilepsy (TLE) patients remain unresponsive to treatment and new drug targets are needed. Connexin-based gap junctions and hemichannels in brain glial cells are implicated in
Anni Guo +7 more
semanticscholar +1 more source
Biology Direct, 2023 Endothelial cell migration is a key process in angiogenesis. Progress of endothelial cell migration is orchestrated by coordinated generation of Ca^2+ signals through a mechanism organized in caveolar microdomains.
H. Espinoza, X. Figueroa
semanticscholar +1 more source
Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Our results demonstrate that connexin 43 hemichannels are the conduits for amyotrophic lateral sclerosis (ALS) astrocyte-mediated motor neuron toxicity and disease spread, acting as a common mechanism that can target both familial ALS and ...
Akshata A Almad +15 more
semanticscholar +1 more source
Divergence between Hemichannel and Gap Junction Permeabilities of Connexin 30 and 26
Life, 2023 Cx30 has been proposed to play physiological functions in the kidney and cochlea, and this has often been associated with its hemichannel role (deafness mutants frequently affecting hemichannels more than gap junctions), implicated in ATP release.
Ji Xu, Bruce J. Nicholson
doaj +1 more source
Following Tracks of Hemichannels [PDF]
Cell Communication & Adhesion, 2003 It has been suggested that plasma membrane-bound hemichannels perform physiological and pathophysiological functions per se. Such functions require the presence of hemichannels on the cell surface and their accessibility to the extracellular environment for at least some limited period of time.
Rolf, Dermietzel +3 more
openaire +3 more sources
The Role of Connexin Hemichannels in Inflammatory Diseases
Biology, 2022 Simple Summary Connexin hemichannels are formed by connexin protein family members, and connect cytosol and extracellular milium. The function of connexin hemichannels cannot be readily distinguished from the gap junctions formed also by connexins, or ...
Bo Peng +4 more
semanticscholar +1 more source
Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells [PDF]
, 2020 Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable.
Bultynck, Geert +10 more
core +1 more source