Results 11 to 20 of about 8,652 (209)
Possible role of hemichannels in cancer. [PDF]
Frontiers in Physiology, 2014 In humans, connexins (Cxs) and pannexins (Panxs) are the building blocks of hemichannels. These proteins are frequently altered in neoplastic cells and have traditionally been considered as tumor suppressors.
Kurt Alex Schalper +3 more
doaj +5 more sources
Connexin hemichannels in the lens [PDF]
Frontiers in Physiology, 2014 The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50).
Eric C Beyer, Viviana M. Berthoud
doaj +5 more sources
Hemichannels: new roles in astroglial function [PDF]
Frontiers in Physiology, 2014 The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of gliotransmitters.
Jimmy eStehberg, Juan Andrés Orellana
doaj +6 more sources
Hunting for connexin hemichannels [PDF]
FEBS Letters, 2014 Connexin hemichannels (connexons) are building blocks of gap junctions but also function as free unapposed channels, which has become an active field of research.
Sáez, Juan C +2 more
core +6 more sources
Voltage-dependent facilitation of Cx46 hemichannels
American Journal of Physiology-Cell Physiology, 2010 Gap junction channels are formed by two hemichannels in series (one from each neighboring cell), which are in turn connexin hexamers. Under normal conditions, hemichannels at the plasma membrane are mostly closed but can be opened by changes in membrane ...
Yin, ShengYong +3 more
core +6 more sources
Connexin hemichannels and cell-cell channels: comparison of properties
Brazilian Journal of Medical and Biological Research, 2000 Connexin46 (Cx46) forms functional hemichannels in the absence of contact by an apposed hemichannel and we have used these hemichannels to study gating and permeation at the single channel level with high time resolution.
V.K. Verselis +2 more
doaj +2 more sources
Nature of plasmalemmal functional “hemichannels” [PDF]
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012 The molecular identity of the protein forming “hemichannels” at non-junctional membranes is disputed. The family of gap junction proteins, innexins, connexins, and pannexins share several common features, including permeability characteristics and ...
Scemes, Eliana, Eliana Scemes
core +3 more sources
Detecting CO2-Sensitive Hemichannels in Neurons in Acute Brain Slices [PDF]
STAR Protocols, 2020 Summary: This protocol provides two independent methods to functionally detect the neuronal expression of CO2-sensitive hemichannels. These hemichannels (consisting of connexins 26 or 30) are directly gated by CO2, independent of pH changes and until ...
Emily Hill, Nicholas Dale, Mark J. Wall
doaj +2 more sources
Dye-uptake Experiment through Connexin Hemichannels
Bio-Protocol, 2014 Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
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The Neuroglial Dialog Between Cannabinoids and Hemichannels [PDF]
Frontiers in Molecular Neuroscience, 2018 The formation of gap junctions was initially thought to be the central role of connexins, however, recent evidence had brought to light the high relevance of unopposed hemichannels as an independent mechanism for the selective release of biomolecules ...
Rosario Gajardo-Gómez +5 more
core +5 more sources