Results 11 to 20 of about 6,486 (158)
Possible role of hemichannels in cancer [PDF]
Frontiers in Physiology, 2014 In humans, connexins (Cxs) and pannexins (Panxs) are the building blocks of hemichannels. These proteins are frequently altered in neoplastic cells and have traditionally been considered as tumor suppressors.
Kurt A Schalper +1 more
exaly +5 more sources
Mechano-activated connexin hemichannels mediate intercellular glutathione transport and support lens redox homeostasis [PDF]
Redox BiologyRedox homeostasis and transparency in the ocular lens are closely associated with the distribution of the antioxidant reduced glutathione (GSH).
Guangyan Wang, Yumeng Quan, Sumin Gu
exaly +4 more sources
Connexin hemichannels in the lens [PDF]
Frontiers in Physiology, 2014 The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50).
Eric C Beyer, Viviana M. Berthoud
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Diseases associated with leaky hemichannels.
Frontiers in Cellular Neuroscience, 2015 Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication.
Mauricio Antonio Retamal +5 more
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Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
Frontiers in Integrative Neuroscience, 2016 Under physiological conditions, astroglial hemichannels and pannexin channels allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory.
Juan A Orellana +2 more
exaly +3 more sources
Hemichannels: new roles in astroglial function [PDF]
Frontiers in Physiology, 2014 The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of gliotransmitters.
Jimmy eStehberg, Juan Andrés Orellana
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Pharmaceuticals, 2022 Inflammation mediators enhance the activity of connexin (Cx) hemichannels, especially in the epithelial and endothelial tissues. As potential release routes for injury signals, such as (oligo)nucleotides, Cx hemichannels may contribute to long-lasting ...
Anne Dierks +7 more
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Frontiers in Cell and Developmental Biology, 2023 Bone adapts to changes in the physical environment by modulating remodeling through bone resorption and formation to maintain optimal bone mass. As the most abundant connexin subtype in bone tissue, connexin 43 (Cx43)-forming hemichannels are highly ...
Dezhi Zhao +6 more
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Role and Posttranslational Regulation of Cx46 Hemichannels and Gap Junction Channels in the Eye Lens
Frontiers in Physiology, 2022 Connexins are a family of proteins that can form two distinct types of channels: hemichannels and gap junction channels. Hemichannels are composed of six connexin subunits and when open allow for exchanges between the cytoplasm and the extracellular ...
Mauricio A. Retamal +3 more
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Divergence between Hemichannel and Gap Junction Permeabilities of Connexin 30 and 26
Life, 2023 Cx30 has been proposed to play physiological functions in the kidney and cochlea, and this has often been associated with its hemichannel role (deafness mutants frequently affecting hemichannels more than gap junctions), implicated in ATP release.
Ji Xu, Bruce J. Nicholson
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