Results 11 to 20 of about 15,292 (254)
Connexin 43 hemichannels and related diseases. [PDF]
Antib TherConnexin 43 (Cx43) protein forms hemichannels (connexons) and gap junctions, with hemichannels consisting of six Cx43 molecules and gap junctions formed by two hemichannels.
Zhang Y, Acosta FM, Jiang JX.
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Calcium Regulation of Connexin Hemichannels
International Journal of Molecular SciencesConnexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are of paramount importance for intercellular communication. In physiological conditions, HCs can form gap junction (GJ) channels, providing a direct diffusive path between ...
Erva Bayraktar +2 more
semanticscholar +4 more sources
Connexin hemichannels in the lens [PDF]
Frontiers in Physiology, 2014 The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50).
Eric C Beyer, Viviana M. Berthoud
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Diseases associated with leaky hemichannels.
Frontiers in Cellular Neuroscience, 2015 Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication.
Mauricio Antonio Retamal +5 more
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Induction of Connexin-hemichannel Opening
Bio-Protocol, 2014 Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
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Restraint stress increases hemichannel activity in hippocampal glial cells and neurons [PDF]
Frontiers in Cellular Neuroscience, 2015 Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression.
Juan Andrés Orellana +6 more
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Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
Frontiers in Integrative Neuroscience, 2016 Under physiological conditions, astroglial hemichannels and pannexin channels allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory.
Juan Andrés Orellana +2 more
exaly +3 more sources
Hemichannels: new roles in astroglial function [PDF]
Frontiers in Physiology, 2014 The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of gliotransmitters.
Jimmy eStehberg, Juan Andrés Orellana
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GJB6 missense variant in a Labrador Retriever with paw pad hyperkeratosis. [PDF]
Anim GenetAbstract Palmoplantar keratoderma in humans is a condition defined by an abnormally thickened cornified skin layer on the hands and feet. In animals, the corresponding disease is commonly termed paw pad hyperkeratosis. It can be acquired due to repeated trauma, infections, cancer, or inflammatory dermatoses, or inherited due to pathogenic variants in ...
Rietmann SJ +3 more
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Pharmaceuticals, 2022 Inflammation mediators enhance the activity of connexin (Cx) hemichannels, especially in the epithelial and endothelial tissues. As potential release routes for injury signals, such as (oligo)nucleotides, Cx hemichannels may contribute to long-lasting ...
Anne Dierks +7 more
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