Results 11 to 20 of about 6,538 (174)
Connexin hemichannels in the lens [PDF]
Frontiers in Physiology, 2014 The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50).
Eric C Beyer, Viviana M. Berthoud
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Hunting for connexin hemichannels [PDF]
FEBS Letters, 2014 Connexin hemichannels (connexons) are building blocks of gap junctions but also function as free unapposed channels, which has become an active field of research. Defining functions of hemichannels and their involvement in any biological event requires ruling out possible participation of other channels that share biophysical and regulatory properties,
Saez, Juan C., Leybaert, Luc
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Connexin 43-Enriched Vesicles Improve Synchronization in hiPSC-Derived Cardiomyocytes. [PDF]
Adv Sci (Weinh)Plasma membrane‐derived Connectosomes enriched in connexin‐43 are produced from donor hiPSCs and applied to hiPSC‐derived cardiomyocytes (hiPSC‐CMs). Connexin‐43 channels on Connectosomes remain functional, strengthening intercellular electrochemical coupling and increasing network synchronization over time.
Momtahan N +8 more
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Hemichannels; from the molecule to the function [PDF]
Frontiers in Physiology, 2014 Coordinated cell interactions are required to accomplish several complex and dynamic tasks observed in several tissues. Cell function may be coordinated by cell-to-cell communication through gap junctions channels (GJCs). These channels are formed by the serial docking of two hemichannels, which in turn are formed by six protein subunits called ...
Retamal, M., Sáez, Juan Carlos
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Frontiers in Physiology, 2014 Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly driven by the release of extracellular ATP through Cx43 hemichannels.
Catheleyne eD'hondt +4 more
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Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading
eLife, 2022 Mechanical stimulation, such as physical exercise, is essential for bone formation and health. Here, we demonstrate the critical role of osteocytic Cx43 hemichannels in anabolic function of bone in response to mechanical loading.
Dezhi Zhao +6 more
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Adhesive properties of connexin hemichannels [PDF]
Glia, 2008 AbstractGap junctions are intercellular channels formed by hemichannels (or connexons) from two neighboring cells. Hemichannels, which are composed of proteins called connexins, can function as conduits of ATP and glutamate, and interact with adhesion molecules and other signaling elements.
M L, Cotrina, J H-C, Lin, M, Nedergaard
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Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria
Molecules, 2017 In addition to gap junctional channels that mediate cell-to-cell communication, connexins form hemichannels that are present at the plasma membrane. Since hemichannels are permeable to small hydrophilic compounds, including metabolites and signaling ...
Mariana C. Fiori +4 more
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Extracellular cysteine in connexins: role as redox sensors
Frontiers in Physiology, 2016 Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Mauricio Antonio Retamal +7 more
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Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments
The Journal of Clinical Investigation, 2023 Connexins are crucial cardiac proteins that form hemichannels and gap junctions. Gap junctions are responsible for the propagation of electrical and chemical signals between myocardial cells and cells of the specialized conduction system in order to ...
Luc Leybaert +8 more
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