Gap junctions and epileptic seizures--two sides of the same coin? [PDF]
PLoS ONE, 2011 Electrical synapses (gap junctions) play a pivotal role in the synchronization of neuronal ensembles which also makes them likely agonists of pathological brain activity.
Vladislav Volman +2 more
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Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals
eLife, 2022 Electrical coupling, mediated by gap junctions, contributes to signal averaging, synchronization, and noise reduction in neuronal circuits. In addition, gap junctions may also provide alternative neuronal pathways.
Munenori Ishibashi +10 more
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Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. [PDF]
PLoS Genetics, 2016 Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear.
Lingfeng Meng, Chia-hui Chen, Dong Yan
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Loss and reappearance of gap junctions in regenerating liver [PDF]
, 1978 Changes in intercellular junctional morphology associated with rat liver regeneration were examined in a freeze-fracture study. After a two-thirds partial hepatectomy, both gap junctions and zonulae occludentes were drastically altered.
Revel, J.-P., Yee, A. G.
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Comparative Analysis of the Major Polypeptides from Liver Gap Junctions and Lens Fiber Junctions [PDF]
, 1982 Gap junctions from rat liver and fiber junctions from bovine lens have similar septilaminar profiles when examined by thin-section electron microscopy and differ only slightly with respect to the packing of intramembrane particles in freeze-fracture ...
Anderson, David J. +3 more
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Connexins in neurons and glia: targets for intervention in disease and injury
Neural Regeneration Research, 2015 Both neurons and glia throughout the central nervous system are organized into networks by gap junctions. Among glia, gap junctions facilitate metabolic homeostasis and intercellular communication.
Keith B Moore, John O′Brien
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Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments
The Journal of Clinical Investigation, 2023 Connexins are crucial cardiac proteins that form hemichannels and gap junctions. Gap junctions are responsible for the propagation of electrical and chemical signals between myocardial cells and cells of the specialized conduction system in order to ...
Luc Leybaert +8 more
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Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors [PDF]
, 2010 Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (
Cursons, Raymond T. +7 more
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Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons
Frontiers in Neural Circuits, 2014 Dye-coupling, whole-mount immunohistochemistry for gap junction channel protein connexin 35 (Cx35), and freeze-fracture replica immunogold labeling (FRIL) reveal an abundance of electrical synapses/gap junctions at glutamatergic mixed synapses in the ...
Jose L Serrano-Velez +8 more
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Frontiers in Cellular Neuroscience, 2021 Electrical synaptic transmission is an essential form of interneuronal communication which is mediated by gap junctions that permit ion flow. Three gene families (connexins, innexins, and pannexins) have evolved to form gap junctional channels.
Qiqian Wang, Shenquan Liu
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