Results 31 to 40 of about 2,988,528 (302)
BMC Cell Biology, 2016 Post-translational modifications of connexins play an important role in the regulation of gap junction and hemichannel permeability. The prerequisite for the formation of functional gap junction channels is the assembly of connexin proteins into ...
K. Pogoda +3 more
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Arrhythmogenic right ventricular cardiomyopathy: considerations from in silico experiments
Frontiers in Physiology, 2012 Objective: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with remodelling of gap junctions and also, although less well-defined, down-regulation of the fast sodium current. The gap junction remodelling and down-regulation of sodium
Ronald eWilders
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Atomic structure of the innexin-6 gap junction channel determined by cryo-EM
Nature Communications, 2016 Innexins, a large protein family comprising invertebrate gap junction channels, play an essential role in nervous system development and electrical synapse formation.
A. Oshima, K. Tani, Y. Fujiyoshi
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Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models
Current Neuropharmacology, 2016 : Background Gap junctions are clusters of intercellular channels allowing the bidirectional pass of ions directly into the cytoplasm of adjacent cells.
J. Manjarrez-Marmolejo +1 more
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An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels
Nature Communications, 2016 Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma.
B. Bennett +9 more
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Connexin’s Connection in Breast Cancer Growth and Progression
International Journal of Cell Biology, 2016 Gap junctions are cell-to-cell junctions that are located in the basolateral surface of two adjoining cells. A gap junction channel is composed of a family of proteins called connexins.
Debarshi Banerjee
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Cell Reports, 2019 Summary: Connexin43 (Cx43; gene name GJA1) is the most ubiquitously expressed gap junction protein, and understanding of its regulation largely falls under transcription and post-translational modification.
Michael J. Zeitz +7 more
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A structural and functional comparison of gap junction channels composed of connexins and innexins
Developmental Neurobiology, 2016 Methods such as electron microscopy and electrophysiology led to the understanding that gap junctions were dense arrays of channels connecting the intracellular environments within almost all animal tissues.
I. M. Skerrett, Jamal B. Williams
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Circulation Research, 2006 See related article, pages 1216–1224 In the late 19th century microscopy and early physiological experimentation gave rise to the apparent paradox that although cardiac muscle is made up of individual cells, it behaves as a single continuous functional unit.
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Gap Junctions in Development [PDF]
American Zoologist, 1986 The concept of a multicellular organism as an assemblage of cells that work together harmoniously for the good of the whole organism is well established. Over the past 15 years, however, it has become increasingly clear that the individual cells of multicellular animals are not as self-sufficient and independent of each other as once had been believed.
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