Results 51 to 60 of about 142,570 (302)

Analysis of the dominant mutation N188T of human connexin46 (hCx46) using concatenation and molecular dynamics simulation

FEBS Open Bio, 2019
Connexins (Cx) are proteins that form cell‐to‐cell gap junction channels. A mutation at position 188 in the second extracellular loop (E2) domain of hCx46 has been linked to an autosomal dominant zonular pulverulent cataract.
Patrik Schadzek, Yannick Stahl, Matthias Preller, Anaclet Ngezahayo   +3 more
doaj   +1 more source

Implication of gap junction coupling in amphibian vitellogenin uptake [PDF]

, 2007
The aim of the present study was to investigate the physiological role and the expression pattern of heterologous gap junctions during Xenopus laevis vitellogenesis.
Villecco, E.I., Monaco, Maria Eugenia, Sanchez, Sara Serafina del V.   +2 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function.

PLoS ONE, 2014
Mutations in GJA5 encoding the gap junction protein connexin40 (Cx40) have been linked to lone atrial fibrillation. Some of these mutants result in impaired gap junction function due to either abnormal connexin localization or impaired gap junction ...
Yiguo Sun, Matthew D Hills, Willy G Ye, Xiaoling Tong, Donglin Bai   +4 more
doaj   +1 more source

An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels

Disease Models & Mechanisms, 2014
Connexin40 (Cx40)-containing gap-junction channels are expressed in the atrial myocardium and provide a low-resistance passage for rapid impulse propagation.
Yiguo Sun, Xiaoling Tong, Honghong Chen, Tao Huang, Qing Shao, Weixiong Huang, Dale W. Laird, Donglin Bai   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Expressional and functional involvement of gap junctions in aqueous humor outflow into the ocular trabecular meshwork of the anterior chamber

Molecular Vision, 2019
Purpose: The ocular trabecular meshwork (TM) responsible for aqueous humor (AH) drainage is crucial for regulating intraocular pressure (IOP) of the eye.
Hongxia, Yongzhen, Wenshi, Xia , Xian , Xiaojing , KeWei, Wei   +7 more
doaj  

Impaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex

Neurobiology of Disease, 2009
Abnormalities in astrocytes occur in the brains of patients with Tuberous Sclerosis Complex (TSC) and may contribute to the pathogenesis of neurological dysfunction in this disease. Here, we report that knock-out mice with Tsc1 gene inactivation in glia (
Lin Xu, Ling-Hui Zeng, Michael Wong
doaj   +1 more source

Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.

PLoS Computational Biology, 2021
Recent experiments in the developing mammalian visual cortex have revealed that gap junctions couple excitatory cells and potentially influence the formation of chemical synapses.
Jennifer Crodelle, David W McLaughlin
doaj   +1 more source

Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2

, 2007
Background: Tight junctions are required for epithelial barrier formation and participate in the regulation of signalling mechanisms that control proliferation and differentiation.
Aijaz Saima, Sanchez-Heras Elena, Balda, MS, Matter Karl, Matter, K, Balda Maria S, Sanchez-Heras, E, Aijaz, S   +7 more
core   +1 more source