Results 71 to 80 of about 142,570 (302)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Why strengthening gap junctions may hinder action potential propagation
Frontiers in Applied Mathematics and StatisticsGap junctions are channels in cell membranes allowing ions to pass directly between cells. They are found throughout the body, including heart myocytes, neurons, and astrocytes. In cardiac tissue and throughout the nervous system, an action potential (AP)
Erin Munro Krull, Christoph Börgers
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
, 2010 Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (
Melin, Sofia M. +15 more
core +1 more source
, 2021 Hypoxia plays an important role in the development of malignant solid tumor and is associated with therapeutic resistance and poor outcome treatment. This condition may be due to the ability of hypoxic cells to influence bystander response through gap ...
Jaikang, Churdsak +20 more
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Gap junction protein connexin43 exacerbates lung vascular permeability. [PDF]
PLoS ONE, 2014 Increased vascular permeability causes pulmonary edema that impairs arterial oxygenation and thus contributes to morbidity and mortality associated with Acute Respiratory Distress Syndrome and sepsis.
James J O'Donnell +3 more
doaj +1 more source
Down-regulation of Connexin 43 mRNA in Mouse Hearts after Myocardial Infarction
, 2003 2003-12Gap junction remodeling have been reported in various types of heart disease. Information available for the gap junction remodeling after myocardial infarction is still limited. In the present study, we investigated mRNA expression of connexin 43 (
Niwa, Noriko +7 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Dense gap-junction connections support dynamic Turing structures in the cortex
, 2007 An open access copy of this article is available and complies with the copyright holder/publisher conditions.The recent report by Fukuda et al [1] provides convincing evidence for dense gap-junction connectivity between inhibitory neurons in the cat ...
Steyn-Ross, D. Alistair +12 more
core +1 more source