Results 81 to 90 of about 393,906 (290)

Gap junction channel gating

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2004
Over the last two decades, the view of gap junction (GJ) channel gating has changed from one with GJs having a single transjunctional voltage-sensitive (V(j)-sensitive) gating mechanism to one with each hemichannel of a formed GJ channel, as well as unapposed hemichannels, containing two, molecularly distinct gating mechanisms.
Bukauskas, Feliksas F, Verselis, Vytas K
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Functional roles of the amino terminal domain in determining biophysical properties of Cx50 gap junction channels

Frontiers in Physiology, 2013
Communication through gap junction channels is essential for synchronized and coordinated cellular activities. The gap junction channel pore size, its switch control for opening/closing, and the modulations by chemicals can be different depending on the ...
Li eXin, Donglin eBai
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis

Mediators of Inflammation, 2020
Sepsis is associated with global cardiac dysfunction and with high mortality rate. The development of septic cardiomyopathy is due to complex interactions of damage-associated molecular patters, cytokines, and complement activation products.
Ina Lackner, Birte Weber, Shinjini Chakraborty, Sonja Braumüller, Markus Huber-Lang, Florian Gebhard, Miriam Kalbitz   +6 more
doaj   +1 more source

Josephson current in unconventional superconductors through an Anderson impurity

, 1999
Josephson current for a system consisting of an Anderson impurity weakly coupled to two unconventional superconductors is studied and shown to be driven by a surface zero energy (mid-gap) bound-state. The repulsive Coulomb interaction in the dot can turn
A. Golub, A. Yazdani, A.A. Golub, A.V. Rozhkov, B. I. Spivak, C. R. Hu, D.J. Van Harlingen, H. Shiba, L.I. Glazman, M.P. Samanta, R.A. Riedel, T.M. Rice, Y. Avishai, Y. Maeno, Y. Tanaka, Y. Tanaka, Y. Tanaka, Yu.S. Barash   +17 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Single-charge devices with ultrasmall Nb/AlOx/Nb trilayer Josephson junctions

, 2004
Josephson junction transistors and 50-junction arrays with linear junction dimensions from 200 nm down to 70 nm were fabricated from standard Nb/AlOx/Nb trilayers.
A. B. Zorin, Averin D. V., H. Scherer, J. Niemeyer, R. Dolata   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Gap acceptance and Driver behavior at intersections in Minna, North Central Nigeria

Nigerian Journal of Technological Development, 2010
The headways, spacing distributions and gap acceptance were measured from two main intersections in Minna, Central Nigeria/The average critical gap and spacing for stadium junction are 2.39 seconds and 11.08m respectively, and that of Mustapha hospital ...
P. N. Ndoke, S. S. Kolo
doaj   +2 more sources