Results 41 to 50 of about 21,628 (300)

Gap Junctions and Connexins in Microglia-Related Oxidative Stress and Neuroinflammation: Perspectives for Drug Discovery

Biomolecules, 2023
Microglia represent the immune system of the brain. Their role is central in two phenomena, neuroinflammation and oxidative stress, which are at the roots of different pathologies related to the central nervous system (CNS).
Giuseppe Caruso, Lucia Di Pietro, Filippo Caraci   +2 more
doaj   +1 more source

Connexin43 in Post-Surgical Peritoneal Adhesion Formation

Life, 2022
Objective: Post-surgical peritoneal adhesions are a serious problem for the quality of life and fertility. Yet there are no effective ways of preventing their occurrence.
Jia Wang Chua, Moogaambikai Thangaveloo, Debbie Xiu En Lim, Leigh E. Madden, Anthony R. J. Phillips, David L. Becker   +5 more
doaj   +1 more source

Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets

Frontiers in Physiology, 2017
Cell-to-cell interaction and cell-to-extracellular environment communication are emerging as new therapeutic targets in neurodegenerative disorders. Dynamic expression of connexins leads to distinctive hemichannels and gap junctions, characterized by ...
Nunzio Vicario, Agata Zappalà, Giovanna Calabrese, Rosario Gulino, Carmela Parenti, Massimo Gulisano, Massimo Gulisano, Rosalba Parenti   +7 more
doaj   +1 more source

The Role of Connexin in Cutaneous Adverse Drug Reactions (CADRs) in Patients with Increasing Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2021
Background: The occurrence of Cutaneous Adverse Drug Reactions (CADRs) is relatively rare but can be fatal when causing organ failure, especially in the liver. The supporting examinations to determine liver injury are aspartate aminotransferase (AST) and
Dyah Ayu Mira Oktarina, Gilang Baswara, Hardyanto Soebono   +2 more
doaj   +1 more source

Connexin: a potential novel target for protecting the central nervous system?

Neural Regeneration Research, 2015
Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and ...
Hong-yan Xie, Yu Cui, Fang Deng, Jia-chun Feng   +3 more
doaj   +1 more source

Macrophage-Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro. [PDF]

FASEB J
Intercellular communication between macrophages and fibroblasts is critical for wound healing. Macrophages promoted fibroblast scratch closure through contact‐dependent mechanisms independent of connexins. In contrast, fibroblasts regulated macrophage cytokine secretion via connexin‐43–mediated contact signaling that increased IL10 and paracrine ...
Enriquez-Ochoa D, Nagalla RR, Liu Y, Guerrero-Juarez CF, Atcha H, Chang G, Morales NA, Hooper HJ, Cano AD, Lim HE, Cahalan MD, Plikus MV, Liu WF.   +12 more
europepmc   +2 more sources

GJA1-20k, a Short Isoform of Connexin43, from Its Discovery to Its Potential Implication in Cancer Progression

Cells
The Connexin43 transmembrane protein (Cx43), encoded by the GJA1 gene, is a member of a multigenic family of proteins that oligomerize to form hemichannels and intercellular channels, allowing gap junctional intercellular communication between adjacent ...
Sarah Fournier, Jonathan Clarhaut, Laurent Cronier, Arnaud Monvoisin   +3 more
doaj   +1 more source

Reduced expression of multiple gap junction proteins is a feature of cervical dysplasia

Molecular Cancer, 2005
Cervical dysplasia is a premalignant lesion associated with human papillomavirus (HPV) infection which, over time, can turn cancerous. Previous studies have indicated that loss of gap junctions may be a feature of cervical cancer and premalignant ...
Edward Mike, Graham Sheila V, Aasen Trond, Hodgins Malcolm B   +3 more
doaj   +1 more source

Regulation of gap junctions by protein phosphorylation

Brazilian Journal of Medical and Biological Research, 1998
Gap junctions are constituted by intercellular channels and provide a pathway for transfer of ions and small molecules between adjacent cells of most tissues.
J.C. Sáez, A.D. Martínez, M.C. Brañes, H.E. González   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source