Results 41 to 50 of about 14,893 (256)

Connexin: a potential novel target for protecting the central nervous system?

Neural Regeneration Research, 2015
Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and ...
Hong-yan Xie, Yu Cui, Fang Deng, Jia-chun Feng   +3 more
doaj   +1 more source

GJA1-20k, a Short Isoform of Connexin43, from Its Discovery to Its Potential Implication in Cancer Progression

Cells
The Connexin43 transmembrane protein (Cx43), encoded by the GJA1 gene, is a member of a multigenic family of proteins that oligomerize to form hemichannels and intercellular channels, allowing gap junctional intercellular communication between adjacent ...
Sarah Fournier, Jonathan Clarhaut, Laurent Cronier, Arnaud Monvoisin   +3 more
doaj   +1 more source

Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets

Frontiers in Physiology, 2017
Cell-to-cell interaction and cell-to-extracellular environment communication are emerging as new therapeutic targets in neurodegenerative disorders. Dynamic expression of connexins leads to distinctive hemichannels and gap junctions, characterized by ...
Nunzio Vicario, Agata Zappalà, Giovanna Calabrese, Rosario Gulino, Carmela Parenti, Massimo Gulisano, Massimo Gulisano, Rosalba Parenti   +7 more
doaj   +1 more source

Reduced expression of multiple gap junction proteins is a feature of cervical dysplasia

Molecular Cancer, 2005
Cervical dysplasia is a premalignant lesion associated with human papillomavirus (HPV) infection which, over time, can turn cancerous. Previous studies have indicated that loss of gap junctions may be a feature of cervical cancer and premalignant ...
Edward Mike, Graham Sheila V, Aasen Trond, Hodgins Malcolm B   +3 more
doaj   +1 more source

Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation

Biomolecules, 2020
Barrier function is a vital homeostatic mechanism employed by epithelial and endothelial tissue. Diseases across a wide range of tissue types involve dynamic changes in transcellular junctional complexes and the actin cytoskeleton in the regulation of ...
Randy E. Strauss, Robert G. Gourdie
doaj   +1 more source

Regulation of gap junctions by protein phosphorylation

Brazilian Journal of Medical and Biological Research, 1998
Gap junctions are constituted by intercellular channels and provide a pathway for transfer of ions and small molecules between adjacent cells of most tissues.
J.C. Sáez, A.D. Martínez, M.C. Brañes, H.E. González   +3 more
doaj   +1 more source

Electrical synaptic transmission requires a postsynaptic scaffolding protein

eLife, 2021
Electrical synaptic transmission relies on neuronal gap junctions containing channels constructed by Connexins. While at chemical synapses neurotransmitter-gated ion channels are critically supported by scaffolding proteins, it is unknown if channels at ...
Abagael M Lasseigne, Fabio A Echeverry, Sundas Ijaz, Jennifer Carlisle Michel, E Anne Martin, Audrey J Marsh, Elisa Trujillo, Kurt C Marsden, Alberto E Pereda, Adam C Miller   +9 more
doaj   +1 more source

Connexins in colorectal cancer pathogenesis

, 2015
International audience: The connexins constitute a family of integral membrane proteins that form channels between adjacent cells. These channels are assembled in plasma membrane domains known as gap junctions and enable cells to directly exchange ions ...
Jarle Bruun, Lothe, Ragnhild A, Edgar Rivedal, Bruun, Jarle, Mesnil, Marc, Matthias Kolberg, Fykerud, Tone A, Lind, Guro E, Sirnes, Solveig, Marc Mesnil, Kolberg, Matthias, Ragnhild A. Lothe, Guro E. Lind, Tone A. Fykerud, Rivedal, Edgar, Edward Leithe, Solveig Sirnes, Leithe, Edward   +17 more
core   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Managing the complexity of communication; regulation of gap junctions by post-translational modification

Frontiers in Pharmacology, 2013
Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information.
Lene Nygaard Axelsen, Kirstine eCalloe, Niels-Henrik eHolstein-Rathlou, Morten Schak Nielsen   +3 more
doaj   +1 more source