Results 51 to 60 of about 38,435 (285)
Connexin: a potential novel target for protecting the central nervous system?
Neural Regeneration Research, 2015 Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and ...
Hong-yan Xie +3 more
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Regulation of gap junction function; the role of nitric oxide. [PDF]
, 2013 Myocardial ischemia resulting from sudden occlusion of a coronary artery is one of the major causes in the appearance of severe, often life-threatening ventricular arrhythmias.
Gönczi, Márton +3 more
core +2 more sources
CellsThe Connexin43 transmembrane protein (Cx43), encoded by the GJA1 gene, is a member of a multigenic family of proteins that oligomerize to form hemichannels and intercellular channels, allowing gap junctional intercellular communication between adjacent ...
Sarah Fournier +3 more
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Regulation of gap junctions by protein phosphorylation
Brazilian Journal of Medical and Biological Research, 1998 Gap junctions are constituted by intercellular channels and provide a pathway for transfer of ions and small molecules between adjacent cells of most tissues.
J.C. Sáez +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 In vitro transdifferentiation of patient-derived mesenchymal stem/stromal cells (MSCs) into neurons is of special interest for treatment of neurodegenerative diseases.
Nadine Dilger +8 more
doaj +1 more source
Connexin Channels, Connexin Mimetic Peptides and ATP Release [PDF]
Cell Communication & Adhesion, 2003 Connexin hemichannels, that is, half gap junction channels (not connecting cells), have been implicated in the release of various messengers such as ATP and glutamate. We used connexin mimetic peptides, which are, small peptides mimicking a sequence on the connexin subunit, to investigate hemichannel functioning in endothelial cell lines.
Leybaert, L. +5 more
openaire +3 more sources
Biomedicines, 2022 Cell-to-cell communication is essential for proper embryonic development and its dysfunction may lead to disease. Recent research has drawn attention to a new group of molecules called connexins (Cxs) and pannexins (Panxs).
Daniela Baracaldo-Santamaría +6 more
doaj +1 more source
In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]
, 2017 We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo +7 more
core +1 more source
Connexins and Pannexins: Important Players in Tumorigenesis, Metastasis and Potential Therapeutics
International Journal of Molecular Sciences, 2018 Since their characterization more than five decades ago, gap junctions and their structural proteins—the connexins—have been associated with cancer cell growth.
S. Graham, Jean X. Jiang, M. Mesnil
semanticscholar +1 more source
Journal of Neural Transplantation and Plasticity, 2018 Neuronal signaling together with synapse activity in the central nervous system requires a precisely regulated microenvironment. Recently, the blood-brain barrier is considered as a “neuro-glia-vascular unit,” a structural and functional compound ...
Yinan Zhao +3 more
semanticscholar +1 more source