Results 61 to 70 of about 14,893 (256)
Advanced Science, EarlyView.A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao +9 more
wiley +1 more source
Connexin 26 and Connexin 43 in Canine Mammary Carcinoma [PDF]
Veterinary Sciences, 2019 Incidence of canine mammary carcinoma is two times higher than the rate of human breast cancer. Mammary tumors are the most common type of cancer in intact female dogs and account for about half of all neoplasms in these dogs. Well-established models of breast cancer have shown that neoplastic cells often have a loss of intercellular communication ...
Savannah Luu +3 more
openaire +2 more sources
Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss
Frontiers in Cell and Developmental Biology, 2022 Pathogenic mutations in the Gjb2 and Gjb6 genes, encoding connexin 26 (Cx26) and connexin 30 (Cx30), respectively, have been linked to the most frequent monogenic hearing impairment, nonsyndromic hearing loss, and deafness DFNB1.
Fabiola Paciello +10 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.Schematic representation of acellular matrix generation from human uterine fibroblast cells, coating on polycaprolactone electrospun nanofibers, and subsequent in vitro and in vivo characterization. A tissue‐engineered scaffold tailored for uterine myometrium‐specific regeneration is designed. The electrospinning technique was used to fabricate aligned
Srividya Hanuman +3 more
wiley +1 more source
Gap junction- and hemichannel-independent actions of connexins [PDF]
, 2005 Connexins have been known to be the protein building blocks of gap junctions and mediate cell–cell communication. In contrast to the conventional dogma, recent evidence suggests that in addition to forming gap junction channels, connexins possess gap ...
Gu, Sumin, Jiang, Jean X.
core +1 more source
The Anatomical Record, EarlyView.Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore +5 more
wiley +1 more source
Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications
BiomedicinesThis article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins
Tatiana Zubareva +7 more
doaj +1 more source
Clinical Anatomy, EarlyView.ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová +11 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2017 Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases.
Liang Xu +45 more
doaj +1 more source
Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley +1 more source