Results 71 to 80 of about 21,628 (300)

Connexin 46 and Connexin 50 in Selenite Cataract

Ophthalmic Research, 2005
The purpose of this work was to determine if the lens gap junction proteins connexin 46 (Cx46) and connexin 50 (Cx50) were altered with the development of selenite-induced cataract. Cataracts were induced in young Sprague-Dawley rats with a single subcutaneous injection of sodium selenite; age-matched uninjected rats served as controls.
openaire   +2 more sources

Clinical Anatomy of the Left and Right Atrial Appendages in Humans: Comparative and Developmental Perspective

Clinical Anatomy, EarlyView.
ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová, Caroline Neradilová, Jan Kovanda, Jan Burkert, Jiří Beneš Jr., Martin Bartos, Theodor Adla, Vojtech Melenovsky, Alena Kvasilova, Ondrej Fabian, Ondrej Naňka, David Sedmera   +11 more
wiley   +1 more source

The action of mimetic peptides on connexins protects fibroblasts from the negative effects of ischemia reperfusion

Biology Open, 2015
Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins.
Beverley J. Glass, Rebecca G. Hu, Anthony R. J. Phillips, David L. Becker   +3 more
doaj   +1 more source

Role of Connexins 30, 36, and 43 in Brain Tumors, Neurodegenerative Diseases, and Neuroprotection

Cells, 2020
Gap junction (GJ) channels and their connexins (Cxs) are complex proteins that have essential functions in cell communication processes in the central nervous system (CNS).
Oscar F. Sánchez, Andrea V. Rodríguez, José M. Velasco-España, Laura C. Murillo, Jhon-Jairo Sutachan, Sonia-Luz Albarracin   +5 more
doaj   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Connexins and Integrins in Exosomes

, 2019
Connexins and integrins, the two structurally and functionally distinct families of transmembrane proteins, have been shown to be inter-connected by various modes of cross-talk in cells, such as direct physical coupling via lateral contact, indirect ...
Arong Gaowa, Shimaoka Motomu, OKAMOTO, Takayuki, Takayuki Okamoto, Eun Park, Eiji Kawamoto, Motomu Shimaoka, Gaowa Arong, Kawamoto Eiji, Park Eun Jeong   +9 more
core   +1 more source

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source

Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders

Frontiers in Molecular Neuroscience, 2017
Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases.
Liang Xu, Liang Xu, Andrea Carrer, Andrea Carrer, Francesco Zonta, Francesco Zonta, Zhihu Qu, Peixiang Ma, Sheng Li, Federico Ceriani, Federico Ceriani, Damiano Buratto, Damiano Buratto, Giulia Crispino, Giulia Crispino, Giulia Crispino, Veronica Zorzi, Veronica Zorzi, Gaia Ziraldo, Gaia Ziraldo, Gaia Ziraldo, Francesca Bruno, Francesca Bruno, Chiara Nardin, Chiara Nardin, Chiara Peres, Flavia Mazzarda, Flavia Mazzarda, Anna M. Salvatore, Marcello Raspa, Ferdinando Scavizzi, Youjun Chu, Sichun Xie, Xuemei Yang, Jun Liao, Xiao Liu, Xiao Liu, Xiao Liu, Wei Wang, Shanshan Wang, Guang Yang, Richard A. Lerner, Fabio Mammano, Fabio Mammano, Fabio Mammano, Fabio Mammano   +45 more
doaj   +1 more source

Bioactive Magnesium Silicate Activating Myocardial Energy Metabolism For Infarcted Myocardium Repair

Exploration, EarlyView.
ABSTRACT The heart is a highly energy‐dependent organ, developing bioenergy‐activating biomaterials to activate myocardial adenosine triphosphate (ATP) production and restore dysregulated energy homeostasis is a promising solution for its functional recovery.
Zhibin Liao, Chen Qin, Erhong Song, Chengbin Ding, Zhixu Wang, Yan Sun, Chen Song, Junjie Liu, Jingge Ma, Hongjian Zhang, Leyu Wang, Chengtie Wu   +11 more
wiley   +1 more source