Results 91 to 100 of about 14,893 (256)
MicroRNAs and Connexins in Bone: Interaction and Mechanisms of Delivery
, 2017 PURPOSE OF REVIEW: To describe the current knowledge on the cross-talk between connexins and microRNAs (miRs) in bone cells. RECENT FINDINGS: Connexins play a crucial role on bone development and maintenance, and disruptions in their abundance or ...
Pacheco-Costa, Rafael +5 more
core +1 more source
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam +3 more
wiley +1 more source
Uncovering the Genetic Landscape of Pediatric Hearing Loss Along the Texas–Mexico Border
Clinical Genetics, EarlyView.Project GIVE provided evaluations and genome sequencing to 23 children with hearing loss along the Texas–Mexico border. Seventy percent received a molecular diagnosis and 56% of those diagnosed had changes to medical management. In this region, underdiagnosis of genetic hearing loss is due to care barriers rather than lower genetic burden.
Desiree Lanehart +17 more
wiley +1 more source
Connexins in Renal Endothelial Function and Dysfunction
, 2014 International audienceThe renal endothelium plays a critical role in kidney physiopathology as it is implicated in various processes such as the regulation of vasomotor tone, the control of tissue inflammation and thrombosis.
Chadjichristos, Christos +4 more
core +1 more source
Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential
Cell Proliferation, EarlyView.CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang +4 more
wiley +1 more source
Connexins: a myriad of functions extending beyond assembly of gap junction channels
Cell Communication and Signaling, 2009 Connexins constitute a large family of trans-membrane proteins that allow intercellular communication and the transfer of ions and small signaling molecules between cells.
Mroue Rana M +3 more
doaj +1 more source
Renal connexins and blood pressure [PDF]
, 2012 The kidneys are centrally involved in the regulation of blood pressure. Kidney function requires the coordinated actions of a number of different vascular and tubular cell types in the renal vasculature and in the renal tubular system.
Kurtz, Armin, Armin Kurtz
core +1 more source
The FEBS Journal, EarlyView.Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
wiley +1 more source
Biology Open, 2015 Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins.
Beverley J. Glass +3 more
doaj +1 more source
The FEBS Journal, EarlyView.Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester +11 more
wiley +1 more source