Results 101 to 110 of about 21,628 (300)
Molecular mechanisms of atherosclerosis: role of connexins
, 2012 Atherosclerosis is an immuno-inflammatory disease of arteries, involving complex intercellular interactions. Direct communication through hemichannels and gap junction channels formed by connexins is important in atherosclerosis.
Pfenniger, Anna
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SnapShot: Connexins and Disease
Cell, 2017 The connexin family of membrane proteins enable gap junction formation and homeostasis, supporting communication between adjacent cells. This SnapShot highlights mutations in different connexins associated with human pathologies and how they affect gap junction function.
Dale W, Laird +2 more
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Connexins as therapeutic targets in neurological and neuropsychiatric disorders
, 2021 Astrocytes represent the reticular part of the central nervous system; gap junctions formed by connexins Cx43, Cx30- and Cx26 provide for homocellular astrocyte-astrocyte coupling, whereas connexins Cx30, Cx32, Cx43, and Cx47 connect astrocytes and ...
Rein, W. +3 more
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British Journal of Pharmacology, EarlyView.Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi +10 more
wiley +1 more source
CO2-Sensitive Connexin Hemichannels in Neurons and Glia: Three Different Modes of Signalling? [PDF]
, 2021 Emily Hill, Nicholas Dale, Mark J. Wall
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Cell Proliferation, EarlyView.This study provides the first definitive identification of tunnelling nanotubes (TNTs) between cultured osteocytes and shows TNT‐mediated lysosome transfer from healthy to stressed cells, restoring autophagic flux and preventing apoptosis. This discovery of transcellular autophagy reveals a new survival mechanism in osteocytes, offering potential ...
Jinbiao Qiang +16 more
wiley +1 more source
Pannexin 1 Is Critically Involved in Feedback from Horizontal Cells to Cones
Frontiers in Molecular Neuroscience, 2017 Retinal horizontal cells (HCs) feed back negatively to cone photoreceptors and in that way generate the center/surround organization of bipolar cell receptive fields. The mechanism by which HCs inhibit photoreceptors is a matter of debate.
Valentina Cenedese +6 more
doaj +1 more source
Regulation of cardiovascular connexins by mechanical forces and junctions
, 2017 Connexins form a family of transmembrane proteins that consists of 20 members in humans and 21 members in mice. Six connexins assemble into a connexon that can function as a hemichannel or connexon that can dock to a connexon expressed by a neighbouring ...
Meens, Merlijn J. +3 more
core
Regulation of connexin expression
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2005 Gap junctions contain cell-cell communicating channels that consist of multimeric proteins called connexins and mediate the exchange of low-molecular-weight metabolites and ions between contacting cells. Gap junctional communication has long been hypothesized to play a crucial role in the maintenance of homeostasis, morphogenesis, cell differentiation,
Oyamada, Masahito +2 more
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The FEBS Journal, EarlyView.Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma +1 more
wiley +1 more source