Results 101 to 110 of about 38,435 (285)

A structural and functional comparison of gap junction channels composed of connexins and innexins

Developmental Neurobiology, 2016
Methods such as electron microscopy and electrophysiology led to the understanding that gap junctions were dense arrays of channels connecting the intracellular environments within almost all animal tissues.
I. M. Skerrett, Jamal B. Williams
semanticscholar   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Dendritic Cell Migration Toward CCL21 Gradient Requires Functional Cx43

Frontiers in Physiology, 2018
Dendritic cells (DCs) travel through lymphatic vessels to transport antigens and present them to T cells in lymph nodes. DCs move directionally toward lymphatics by virtue of their CCR7 and a CCL21 chemotactic gradient.
Richard Ruez, Juan Dubrot, Alice Zoso, Marc Bacchetta, Filippo Molica, Stéphanie Hugues, Brenda R. Kwak, Marc Chanson   +7 more
doaj   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling: The Role of Interleukin‐6–Mediated Changes in Connexin Expression

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Systemic inflammation is a strong predictor of atrial fibrillation. A key role for electrical remodeling is increasingly recognized, and experimental data suggest that inflammatory cytokines can directly affect connexins resulting in gap ...
Pietro Enea Lazzerini, Franco Laghi‐Pasini, Maurizio Acampa, Ujala Srivastava, Iacopo Bertolozzi, Beatrice Giabbani, Francesco Finizola, Francesca Vanni, Aleksander Dokollari, Mariarita Natale, Gabriele Cevenini, Enrico Selvi, Nicola Migliacci, Massimo Maccherini, Mohamed Boutjdir, Pier Leopoldo Capecchi   +15 more
doaj   +1 more source

Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions

Frontiers in Molecular Neuroscience, 2016
Under physiological conditions, microglia adopt a resting phenotype associated with the production of anti-inflammatory and neurotrophic factors. In response to a wide variety of insults, these cells shift to an activated phenotype that is necessary for ...
Rosario Gajardo-Gómez, Valeria C. Labra, J. Orellana   +2 more
semanticscholar   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Gap junctions in the cardiovascular and immune systems

Brazilian Journal of Medical and Biological Research, 2000
Gap junctions are clusters of intercellular channels directly connecting the cytoplasm of adjacent cells. These channels are formed by proteins named connexins and are present in all metazoan organisms where they serve diverse functions ranging from ...
R. Rozental, A.C. Campos-de-Carvalho, D.C. Spray   +2 more
doaj   +1 more source

Connexins and pannexins in neuronal development and adult neurogenesis

BMC Cell Biology, 2016
Connexins and pannexins share very similar structures and functions; they also exhibit overlapping expression in many stages of neuronal development. Here, we review evidence implicating connexin- and pannexin-mediated communication in the regulation of ...
L. A. Swayne, S. Bennett
semanticscholar   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source