Results 121 to 130 of about 38,435 (285)

Effect of Zinc Oxide Nanoparticles From Infant Formula Milk Powder on Colon Cells In Vitro

Journal of Applied Toxicology, EarlyView.
ABSTRACT Zinc is an essential trace element that participates in numerous metabolic processes; however, excessive exposure may interfere with the absorption of other metals, such as copper. In recent years, nanotechnology has experienced rapid growth, and zinc oxide nanoparticles (ZnO NPs) have garnered significant attention due to their versatile ...
Gloria Salinas‐Lucero, Karla Juarez‐Moreno, Rafael Vazquez‐Duhalt   +2 more
wiley   +1 more source

Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders

Frontiers in Molecular Neuroscience, 2017
Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases.
Liang Xu, Liang Xu, Andrea Carrer, Andrea Carrer, Francesco Zonta, Francesco Zonta, Zhihu Qu, Peixiang Ma, Sheng Li, Federico Ceriani, Federico Ceriani, Damiano Buratto, Damiano Buratto, Giulia Crispino, Giulia Crispino, Giulia Crispino, Veronica Zorzi, Veronica Zorzi, Gaia Ziraldo, Gaia Ziraldo, Gaia Ziraldo, Francesca Bruno, Francesca Bruno, Chiara Nardin, Chiara Nardin, Chiara Peres, Flavia Mazzarda, Flavia Mazzarda, Anna M. Salvatore, Marcello Raspa, Ferdinando Scavizzi, Youjun Chu, Sichun Xie, Xuemei Yang, Jun Liao, Xiao Liu, Xiao Liu, Xiao Liu, Wei Wang, Shanshan Wang, Guang Yang, Richard A. Lerner, Fabio Mammano, Fabio Mammano, Fabio Mammano, Fabio Mammano   +45 more
doaj   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

Connexin-mediated signaling in nonsensory cells is crucial for the development of sensory inner hair cells in the mouse cochlea [PDF]

, 2017
open9siMutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and humans.

core   +1 more source

Connexin 46 and Connexin 50 in Selenite Cataract

Ophthalmic Research, 2005
The purpose of this work was to determine if the lens gap junction proteins connexin 46 (Cx46) and connexin 50 (Cx50) were altered with the development of selenite-induced cataract. Cataracts were induced in young Sprague-Dawley rats with a single subcutaneous injection of sodium selenite; age-matched uninjected rats served as controls.
openaire   +2 more sources

Seeing Invisible Oligomers: Rethinking α‐Synuclein Pathology Through Proximity Ligation Assay

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) and multiple system atrophy are defined by α‐synuclein (αSYN)‐positive inclusions – Lewy bodies (LBs) and glial cytoplasmic inclusions – yet mounting evidence indicates that these inclusions represent only a fraction of disease‐relevant pathology.
Hiroaki Sekiya, Nanna Møller Jensen, Dennis W. Dickson, Poul Henning Jensen   +3 more
wiley   +1 more source

Nitric oxide enhances de novo formation of endothelial gap junctions [PDF]

, 2003
Objective: Gap junctions (formed by connexins, Cx) are important for functional coordination of cells in the vascular wall. However, little is known about their physiological regulation in this tissue.
Gloe, Torsten, Hoffmann, Anke, Pohl, Ulrich, Zahler, Stefan   +3 more
core   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Mind the gap: connexins and cell–cell communication in the diabetic kidney [PDF]

, 2015
Connexins, assembled as a hexameric connexon, form a transmembrane hemichannel that provides a conduit for paracrine signalling of small molecules and ions to regulate the activity and function of adjacent cells.
A Abed, A Awad, A Cove-Smith, A Kurtz, A Mendoza-Naranjo, A Pfenniger, A Sipos, AF Li, AF Li, BN Giepmans, C Qiu, C Wagner, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, Claire E. Hills, CM Wang, CS Wright, D Bosco, D Lu, DW Laird, E Yaoita, F Hanner, F Mumtaz, G Sahu, Gareth W. Price, GS Goldberg, GS Hillis, GS Hillis, I Loeffler, J Gilleron, J Kronengold, J Wada, J Yao, J Yao, J Yao, J Zhang, JA Haefliger, JA Haefliger, JA Wright, JC Herve, JH Zhang, K Fujimoto, K Sawai, L Gal Le, L Liu, M Dalla Vestra, M Firouzi, M Gerl, M Oppermann, M Oyamada, MA Retamal, MS Nielsen, MW Bobbie, N Defamie, N Krattinger, N Wang, P Svenningsen, Paul E. Squires, PD Lampe, Q Yan, R Hernández-Salinas, R Hirschberg, RM Mege, S Tsuchida, SP Prabhakar, SS Prabhakar, T Inoguchi, T Morioka, T Sato, T Takenaka, T Takenaka, T Tien, WM Jongen, X Xie, X Zhang, Y Liu, Y Suzaki, YC Lee   +82 more
core   +1 more source

Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis

Allergy, EarlyView.
ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki, Kazunari Sugita, Zenas Yiu, Sandra Díez‐Ribas, Irene Garcia‐Jimenez, Emma Guttman‐Yassky, Luis F. Santamaria‐Babí   +6 more
wiley   +1 more source