Results 111 to 120 of about 11,327 (216)
Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen +1 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 8, Page 1933-1962, August 2026.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, Volume 20, Issue 8, Page 1895-1904, August 2026.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma
Cancer Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background Glioblastoma (GB) is the most aggressive primary malignant brain tumor in adults and remains associated with poor survival despite surgical resection followed by radiotherapy and temozolomide (TMZ) chemotherapy. Intrinsic and acquired resistance to TMZ, including MGMT‐dependent DNA repair and activation of pro‐survival pathways ...
Ali Nakhaei +5 more
wiley +1 more source
Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases
Comprehensive Physiology, Volume 16, Issue 4, August 2026.Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal +2 more
wiley +1 more source
Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes
Glia, Volume 74, Issue 8, August 2026.Cerebellar Olig2 positive astrocytes are most abundant in the cerebellar nuclei. Cerebellar astrocytes expressing Olig2 have unique gene expression profiles. Yin Yang 1 specifically supports the development of astrocytes expressing Olig2. Deletion of YY1 during development increases numbers of astrocytes expressing Olig2 but hinders their ...
Masoumeh Zarei‐Kheirabadi +9 more
wiley +1 more source
Serine Ameliorates Cadmium‐Induced Testicular Injury by Regulating the PGAM1/PHGDH Signaling Pathway
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.Serine mitigates cadmium‐induced testicular injury in mice by inhibiting the PGAM1/PHGDH pathway, restoring ion homeostasis and glycolysis, and relieving oxidative stress, inflammation, fibrosis, and apoptosis. ABSTRACT Cadmium (Cd) is a widespread environmental contaminant that impairs male reproductive function; however, the metabolic mechanisms ...
Xueru Wang +8 more
wiley +1 more source
Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?
Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange +4 more
wiley +1 more source
Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions
MedComm, Volume 7, Issue 8, August 2026.This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei +9 more
wiley +1 more source