Results 21 to 30 of about 11,327 (216)
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010 Connexins (Cxs) are widely-expressed proteins that form gap junctions in most organs, including the kidney. In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the vascular smooth muscle cells. In the tubules, there is morphological evidence for the presence of gap
Hanner, Fiona +3 more
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Connexin’s Connection in Breast Cancer Growth and Progression
International Journal of Cell Biology, 2016 Gap junctions are cell-to-cell junctions that are located in the basolateral surface of two adjoining cells. A gap junction channel is composed of a family of proteins called connexins.
Debarshi Banerjee
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013 Atherosclerosis, a chronic inflammatory disease of the vessel wall, involves multiple cell types of different origins, and complex interactions and signaling pathways between them. Autocrine and paracrine communication pathways provided by cytokines, chemokines, growth factors and lipid mediators are central to atherogenesis.
Pfenniger, Anna +2 more
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Connexin Mutants and Cataracts [PDF]
Frontiers in Pharmacology, 2013 The lens is a multicellular, but avascular tissue that must stay transparent to allow normal transmission of light and focusing of it on the retina. Damage to lens cells and/or proteins can cause cataracts, opacities that disrupt these processes.
Beyer, Eric C. +2 more
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Gap junction protein connexin43 exacerbates lung vascular permeability. [PDF]
PLoS ONE, 2014 Increased vascular permeability causes pulmonary edema that impairs arterial oxygenation and thus contributes to morbidity and mortality associated with Acute Respiratory Distress Syndrome and sepsis.
James J O'Donnell +3 more
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Connexin43 in Post-Surgical Peritoneal Adhesion Formation
Life, 2022 Objective: Post-surgical peritoneal adhesions are a serious problem for the quality of life and fertility. Yet there are no effective ways of preventing their occurrence.
Jia Wang Chua +5 more
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Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2021 Background: The occurrence of Cutaneous Adverse Drug Reactions (CADRs) is relatively rare but can be fatal when causing organ failure, especially in the liver. The supporting examinations to determine liver injury are aspartate aminotransferase (AST) and
Dyah Ayu Mira Oktarina +2 more
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Connexin: a potential novel target for protecting the central nervous system?
Neural Regeneration Research, 2015 Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and ...
Hong-yan Xie +3 more
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Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets
Frontiers in Physiology, 2017 Cell-to-cell interaction and cell-to-extracellular environment communication are emerging as new therapeutic targets in neurodegenerative disorders. Dynamic expression of connexins leads to distinctive hemichannels and gap junctions, characterized by ...
Nunzio Vicario +7 more
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CellsThe Connexin43 transmembrane protein (Cx43), encoded by the GJA1 gene, is a member of a multigenic family of proteins that oligomerize to form hemichannels and intercellular channels, allowing gap junctional intercellular communication between adjacent ...
Sarah Fournier +3 more
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