Results 21 to 30 of about 14,893 (256)
Endocytic trafficking of connexins in cancer pathogenesis [PDF]
, 2023 Cancer; Connexin; UbiquitinCàncer; Connexina; UbiquitinaCáncer; Conexina; UbiquitinaGap junctions are specialized regions of the plasma membrane containing clusters of channels that provide for the diffusion of ions and small molecules between adjacent ...
Sørensen, Vigdis +12 more
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Nitric oxide enhances de novo formation of endothelial gap junctions [PDF]
, 2003 Objective: Gap junctions (formed by connexins, Cx) are important for functional coordination of cells in the vascular wall. However, little is known about their physiological regulation in this tissue.
Gloe, Torsten +3 more
core +1 more source
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010 Connexins (Cxs) are widely-expressed proteins that form gap junctions in most organs, including the kidney. In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the vascular smooth muscle cells. In the tubules, there is morphological evidence for the presence of gap
Hanner, Fiona +3 more
openaire +4 more sources
Connexins—Therapeutic Targets in Cancers
, 2020 Connexins (Cx) are members of a protein family that forms intercellular channels localised in gap junction (GJ) plaques and single transmembrane channels called hemichannels.
Martyna Opara-Bajerowicz +4 more
core +1 more source
Antioxidants, 2021 The lens is continuously exposed to oxidative stress insults, such as ultraviolet radiation and other oxidative factors, during the aging process. The lens possesses powerful oxidative stress defense systems to maintain its redox homeostasis, one of ...
Yumeng Quan +4 more
doaj +1 more source
Gap-junctional coupling between neutrophils and endothelial cells [PDF]
, 2003 Communication between leukocytes and endothelial cells is crucial for inflammatory reactions. Paracrine cross-talk and outside-in signaling (via adhesion molecules) have been characterized as communication pathways to date.
Gloe, Torsten +3 more
core +1 more source
The role of connexins in wound healing and repair: novel therapeutic approaches
Frontiers in Physiology, 2016 Gap junctions are intercellular proteins responsible for mediating both electrical and biochemical coupling through the exchange of ions, second messengers and small metabolites.
Jeremy Wong +7 more
doaj +1 more source
Connexins and pannexins in liver damage [PDF]
, 2016 Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function these proteins are frequently involved in pathological processes.
Cogliati, Bruno +7 more
core +1 more source
Connexin Hemichannels in Astrocytes: Role in CNS Disorders
Frontiers in Molecular Neuroscience, 2019 In the central nervous system (CNS), astrocytes form networks interconnected by gap junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an adjoining hemichannel, astrocytic connexins can act as hemichannels to control the ...
LingYan Xing +4 more
doaj +1 more source
Biomolecules, 2023 Microglia represent the immune system of the brain. Their role is central in two phenomena, neuroinflammation and oxidative stress, which are at the roots of different pathologies related to the central nervous system (CNS).
Giuseppe Caruso +2 more
doaj +1 more source