Results 11 to 20 of about 14,893 (256)
Cardiology Research and Practice, 2012 Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further ...
Josephine A. Wright +2 more
doaj +5 more sources
Cold Spring Harbor Perspectives in Biology, 2017 Inherited or acquired alterations in the structure and function of connexin proteins have long been associated with disease. In the present work, we review current knowledge on the role of connexins in diseases associated with the heart, nervous system ...
Naus, Christian C +11 more
core +4 more sources
Connexins in atherosclerosis [PDF]
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013 Atherosclerosis, a chronic inflammatory disease of the vessel wall, involves multiple cell types of different origins, and complex interactions and signaling pathways between them.
Pfenniger, Anna +3 more
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Connexins are mechanosensitive
American Journal of Physiology-Cell Physiology, 2004 Connexins form gap junction channels that provide a hydrophilic path between cell interiors. Some connexins, particularly the lens connexins, Cx46 and Cx50 and their orthologs, can form functional hemichannels in nonjunctional membranes.
Dahl, Gerhard +2 more
core +3 more sources
Journal of Biomedical Science, 2019 Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions among neighboring cells and thus facilitates gap junctional intercellular communication (GJIC).
Jun-I Wu, Lu-Hai Wang
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Endothelial connexins in vascular function
Vascular Biology, 2019 Gap junctions are essential for intercellular crosstalk in blood and lymphatic vasculature. These clusters of intercellular channels ensure direct communication among endothelial cells and between endothelial and smooth muscle cells, and the ...
Aurélie Hautefort +2 more
doaj +2 more sources
Biology of the Cell, 2002 Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues.
Serre Beinier, Véronique +17 more
core +5 more sources
Brazilian Journal of Medical and Biological Research, 2000 Intercellular communication may be regulated by the differential expression of subunit gap junction proteins (connexins) which form channels with differing gating and permeability properties.
Beyer E.C. +5 more
doaj +1 more source
Connexins and the Epithelial Tissue Barrier: A Focus on Connexin 26 [PDF]
Biology, 2021 Epithelial tissue responds rapidly to environmental triggers and is constantly renewed. This tissue is also highly accessible for therapeutic targeting. This review highlights the role of connexin mediated communication in avascular epithelial tissue.
Laura Garcia-Vega +3 more
openaire +3 more sources
Connexins in the skeleton [PDF]
Seminars in Cell & Developmental Biology, 2016 Shaping of the skeleton (modeling) and its maintenance throughout life (remodeling) require coordinated activity among bone forming (osteoblasts) and resorbing cells (osteoclasts) and osteocytes (bone embedded cells). The gap junction protein connexin43 (Cx43) has emerged as a key modulator of skeletal growth and homeostasis. The skeletal developmental
Joseph P, Stains, Roberto, Civitelli
openaire +2 more sources