Results 11 to 20 of about 21,628 (300)
Cardiology Research and Practice, 2012 Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further ...
Toby Richards +2 more
core +4 more sources
Connexins in Cancer: Jekyll or Hyde?
Biomolecules, 2020 The expression, localization, and function of connexins, the protein subunits that comprise gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap junction channels, connexins also form hemichannels that allow ...
Erin E Mulkearns-Hubert +2 more
exaly +4 more sources
Coordination of innate immune responses by connexins. [PDF]
Front ImmunolInnate immunity comprises intricate cellular and tissue responses critical for host defense and tissue homeostasis. Intercellular communication is central to these responses and significantly influences infection, inflammatory disorders, and cancer ...
Wu Q, Zhao T, Xu P.
europepmc +4 more sources
Astroglial Connexins in Neurodegenerative Diseases [PDF]
Frontiers in Molecular Neuroscience, 2021 Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, a process called reactive ...
Su, Y +8 more
core +3 more sources
Regulation of cardiovascular connexins by mechanical forces and junctions
Cardiovascular Research, 2013 Connexins form a family of transmembrane proteins that consists of 20 members in humans and 21 members in mice. Six connexins assemble into a connexon that can function as a hemichannel or connexon that can dock to a connexon expressed by a neighbouring ...
Merlijn J Meens +2 more
exaly +2 more sources
Role of connexins and pannexins in cardiovascular physiology
Cellular and Molecular Life Sciences, 2015 Connexins and pannexins form connexons, pannexons and membrane channels, which are critically involved in many aspects of cardiovascular physiology.
Merlijn J Meens +2 more
exaly +2 more sources
Connexins participate in the initiation and progression of atherosclerosis
Seminars in Immunopathology, 2009 Connexins are members of a large family of transmembrane proteins that form hemichannels or gap junctions. These channels allow the exchange of ions and small metabolites between the cytosol and extracellular space or between neighboring cells. Connexins
Sandrine Morel +2 more
exaly +2 more sources
Cold Spring Harbor Perspectives in Biology, 2017 Inherited or acquired alterations in the structure and function of connexin proteins have long been associated with disease. In the present work, we review current knowledge on the role of connexins in diseases associated with the heart, nervous system ...
Naus, Christian C +11 more
core +5 more sources
Journal of Biomedical Science, 2019 Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions among neighboring cells and thus facilitates gap junctional intercellular communication (GJIC).
Lu-Hai Wang, Jun-I Wu
core +3 more sources
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013 Atherosclerosis, a chronic inflammatory disease of the vessel wall, involves multiple cell types of different origins, and complex interactions and signaling pathways between them.
Pfenniger, Anna +3 more
core +5 more sources