Results 11 to 20 of about 11,327 (216)
Cardiology Research and Practice, 2012 Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further ...
Josephine A. Wright +2 more
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Connexins and the Epithelial Tissue Barrier: A Focus on Connexin 26 [PDF]
Biology, 2021 Epithelial tissue responds rapidly to environmental triggers and is constantly renewed. This tissue is also highly accessible for therapeutic targeting. This review highlights the role of connexin mediated communication in avascular epithelial tissue.
Laura Garcia-Vega +3 more
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Cold Spring Harbor Perspectives in Biology, 2017 Inherited or acquired alterations in the structure and function of connexin proteins have long been associated with disease. In the present work, we review current knowledge on the role of connexins in diseases associated with the heart, nervous system, cochlea, and skin, as well as cancer and pleiotropic syndromes such as oculodentodigital dysplasia ...
Delmar, Mario +5 more
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Connexins in the skeleton [PDF]
Seminars in Cell & Developmental Biology, 2016 Shaping of the skeleton (modeling) and its maintenance throughout life (remodeling) require coordinated activity among bone forming (osteoblasts) and resorbing cells (osteoclasts) and osteocytes (bone embedded cells). The gap junction protein connexin43 (Cx43) has emerged as a key modulator of skeletal growth and homeostasis. The skeletal developmental
Joseph P, Stains, Roberto, Civitelli
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Atrial Fibrillation: Focus on Myocardial Connexins and Gap Junctions
Biology, 2022 Atrial fibrillation (AF) represents the most common type of clinical cardiac arrhythmia worldwide and contributes to substantial morbidity, mortality and socioeconomic burden. Aggregating evidence highlights the strong genetic basis of AF. In addition to
Yu-Han Guo, Yi-Qing Yang
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Journal of Biomedical Science, 2019 Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions among neighboring cells and thus facilitates gap junctional intercellular communication (GJIC).
Jun-I Wu, Lu-Hai Wang
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Antioxidants, 2021 The lens is continuously exposed to oxidative stress insults, such as ultraviolet radiation and other oxidative factors, during the aging process. The lens possesses powerful oxidative stress defense systems to maintain its redox homeostasis, one of ...
Yumeng Quan +4 more
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Connexin Channels, Connexin Mimetic Peptides and ATP Release [PDF]
Cell Communication & Adhesion, 2003 Connexin hemichannels, that is, half gap junction channels (not connecting cells), have been implicated in the release of various messengers such as ATP and glutamate. We used connexin mimetic peptides, which are, small peptides mimicking a sequence on the connexin subunit, to investigate hemichannel functioning in endothelial cell lines.
Leybaert, L. +5 more
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Connexin Hemichannels in Astrocytes: Role in CNS Disorders
Frontiers in Molecular Neuroscience, 2019 In the central nervous system (CNS), astrocytes form networks interconnected by gap junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an adjoining hemichannel, astrocytic connexins can act as hemichannels to control the ...
LingYan Xing +4 more
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Biomolecules, 2023 Microglia represent the immune system of the brain. Their role is central in two phenomena, neuroinflammation and oxidative stress, which are at the roots of different pathologies related to the central nervous system (CNS).
Giuseppe Caruso +2 more
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