Results 251 to 260 of about 1,332,853 (314)

Solidarity or Segregation? ChatGPT Health and US Health Care Disparities. [PDF]

J Med Internet Res
Barnhart AJ, Comerci G, Prainsack B, Braun M.   +3 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Treatment for Hyperosmolar Dehydration in Hospitalised Adults: Protocol for a Scoping Review of Current Evidence and Gaps. [PDF]

JMIR Res Protoc
Hansen CH, Mortensen LT, Brandstrup B, Beck AM, Andersen S, Danielsen MB.   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mapping morbidity data and identifying data gaps for EU countries in the Global Burden of Disease 2023 study. [PDF]

J Public Health (Oxf)
Hrzic R, Wyper GMA, Mechili EA, Unim B, Freitas A, Santric Milicevic M, Caballero I, Santos JV.   +7 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Sex-related differences in final knee balance during robotic-assisted unicompartmental knee arthroplasty. [PDF]

Arch Orthop Trauma Surg
Stimolo D, Leggieri F, Secci G, Massenzi M, Civinini R, Innocenti M.   +5 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Applying the Bow Tie Method to Evaluate Emerging Risk: The Case of Carbon Capture and Water Stress. [PDF]

Risk Anal
Weisner MJ, Paglioni VP, Scott RP.
europepmc   +1 more source

Preparing the Frontline: Profiling Knowledge, Attitudes, and Practice Gaps in Healthcare-Associated Infection Prevention Among Future Health Professionals in Belize. [PDF]

Interdiscip Perspect Infect Dis
Husaini DC, Punjabi S, Guild T, Solis E, Abubakar Y.   +4 more
europepmc   +1 more source