Results 201 to 210 of about 440,316 (302)

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Bevacizumab-Associated Bowel Perforation Causing Evisceration. [PDF]

Cureus
Fazel Darbandi M, Johnson G, Hardy K, Vergis A.   +3 more
europepmc   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Efficacy of Platelet-Rich Plasma, Mesenchymal Stromal Cells, and Hyaluronic Acid in Preventing Adhesions After Zone II Flexor Tendon Repair: A Narrative Review. [PDF]

Cureus
Rutt GJ, Esch CE, Ballantyne M.
europepmc   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Epidemiology and pharmacological management of new onset atrial fibrillation in critically ill adults: A multicentre observational study. [PDF]

Crit Care Resusc
Denny KJ, Whebell S, McCullough JPA, Laupland KB, Blank S, Tabah A, Shekar K, Garrett P, Ramanan M, Attokaran AG, Raith E, Walker HGM, Brown A, White KC, Queensland Critical Care Research Network (QCCRN).   +14 more
europepmc   +1 more source

Social and Emotional Functions of Institutional Touch in the Relational Care of Young Children

Child &Family Social Work, EarlyView.
ABSTRACT This study reports results concerning close embodied practices, involving touch, in early childhood care settings in Sweden during the COVID‐19 pandemic. The data—video recordings of everyday practices in contexts of childcare—were collected during various phases of the pandemic. The study demonstrates a broad range of uses of touch, by adults
Asta Cekaite, Madeleine Wirzén
wiley   +1 more source

A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin γC5 isoform is not essential for dendrite arborization in the cerebral cortex. [PDF]

PLoS One
Hanes CM, Steffen DM, Murray GC, Burgess RW, Weiner JA, Garrett AM.   +5 more
europepmc   +1 more source

Use of andexanet alfa: A British Society for Haematology position statement

British Journal of Haematology, EarlyView.
Richard J. Buka, Deepa J. Arachchillage, Catherine N. Bagot, Gary Benson, Charlotte A. Bradbury, Nicola Curry, Beverley J. Hunt, David J. Sutton, Mari R. Thomas, John Paul Westwood, Karen Breen   +10 more
wiley   +1 more source

Between Care and Control: Age Assessments and the Regulation of Unaccompanied and Asylum‐Seeking Children

Child &Family Social Work, EarlyView.
ABSTRACT This article offers a critical conceptual review of age assessments in England and examines their implications for unaccompanied asylum‐seeking children (UASC). Drawing on Foucault's theories of biopower and governmentality, age assessments are conceptualied as technologies of control that set the parameters for who is deemed ‘deserving’ of ...
Ama‐Rose Greaves
wiley   +1 more source