Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng +6 more
wiley +1 more source
Decoding the Unseen: A Systematic Review of the Analytical Performance of Nitazene Test Strips for Identifying Synthetic Opioids in Seized Drug Materials. [PDF]
Al-Juhani A +7 more
europepmc +1 more source
Beyond Traditional RAFT Polymerization: Emerging Strategies and Future Perspectives; A Third Update
This review explores recent advances in the past five years for non‐traditional RAFT polymerization, focusing on new activation strategies, sustainable depolymerization, and integration with automated and AI‐driven synthesis. Together, these innovations advance polymer chemistry and reveal how the pieces of the non‐traditional RAFT puzzle are steadily ...
Vianna F. Jafari +10 more
wiley +1 more source
Fecal butyrate and deoxycholic acid quantitation for rapid assessment of the gut microbiome. [PDF]
Mullowney MW +13 more
europepmc +1 more source
H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou +12 more
wiley +1 more source
Thermal cyclotrimerization of nitriles converts interfacial discontinuity in MAF‐stu‐1/PIM‐1 MMMs into a continuity‐enhanced junction. Triazine–Zn2+ coordination between TR‐PIM chains and MAF‐stu‐1, together with hydrogen bonding and π–π stacking, lowers interfacial tension and builds selective CO2 pathways, enabling > 10 000 barrer CO2 permeability ...
Zhihong Lin +7 more
wiley +1 more source
Toxic Tear Gas 2-Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure. [PDF]
Sieber PH, Steinritz D, Worek F, John H.
europepmc +1 more source
Deuterated MOFs in this work exhibited unprecedented giant luminescence isotope effect via O─H oscillator suppression, achieving maximal solid‐state materials emission enhancement. This yields significantly improved X‐ray detection sensitivity and imaging resolution, marking the first integration of MOFs with isotopic luminescence and opening new ...
Junhao Lu +16 more
wiley +1 more source
Identification of biomarkers for renal cell carcinoma in plasma samples measured using liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. [PDF]
Zhai K +7 more
europepmc +1 more source
Asymmetric Cu–Zn dual sites on EDTA‐grafted Ti‐MOF amplify the dipole‐limiting domain field (DLDF), facilitating C–C coupling. This strategy yields an exceptional C2H4 production rate of 308.72 µmol g−1 h−1 with 98.4% electron selectivity in photocatalytic CO2 reduction, highlighting the potential of asymmetric site engineering and local field ...
Peidong Ma +8 more
wiley +1 more source

