Results 201 to 210 of about 317,828 (221)

Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease

open access: yesAggregate, EarlyView.
This review introduces the light‐regulated Aβ aggregation, highlighting four applications: photodynamic therapy (PDT), photothermal therapy (PTT), photopharmacology, and photobiomodulation (PBM) systems. It also summarizes the current issues and proposes the prospects of photo‐induced modulation of Aβ aggregation and clearance as a therapeutic strategy
Yunhua Zhang   +4 more
wiley   +1 more source

Impact of Host–Emitter Interactions on Light Amplification in Laser Dyes

open access: yesAggregate, EarlyView.
A new organic semiconductor laser material, QSBCz, based on stilbene tetramer, is presented. Compared to high‐performance laser material with stilbene dimer, BSBCz, increased conjugation contributes to enhancing radiative rate constant and gain cross‐section.
Masashi Mamada   +7 more
wiley   +1 more source

Density Functional Theory–Spectroscopy Integrated Identification Method Encompassing Experimental and Theoretical Analyses for Designer Drug Stimulants

open access: yesAdvanced Intelligent Systems, EarlyView.
A novel approach integrates gas chromatography‐mass spectrometry with infrared, Raman, and nuclear magnetic resonance spectroscopy plus density functional theory to detect synthetic drugs. Quantum hyperpolarization further boosts NMR sensitivity for low‐concentration samples, improving detection accuracy in complex mixtures and offering promising ...
Keunhong Jeong   +8 more
wiley   +1 more source

A Triptycene‐Based Cage Host for Aromatic Hydrocarbon Guests

open access: yesAsian Journal of Organic Chemistry, EarlyView.
A molecular cage consisting of two tripodal triptycene units and three diphenylacetylene linkers includes aromatic guests such as anthracene, acenaphthylene, and pyrene into the cavity. The association constants of the host–guest complexation were determined by the 1H NMR titration.
Takuji Mitani   +4 more
wiley   +1 more source

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction

open access: yesAlzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Human tau protein, composed of six brain‐specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout (KO) induced pluripotent stem cells (iPSC) using CRISPR/Cas9, differentiated these into ...
Sarah Buchholz   +11 more
wiley   +1 more source

Identifying the optimal dose of cannabidiol by intrabuccal administration in Kramnik (C3HeB/FeJ) mice

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Cannabidiol (CBD) has numerous therapeutic properties, and is used to treat neurological conditions, such as neuroinflammation. However, the optimal dose of CBD to penetrate the brain requires further investigation. The primary aim of this study was to use a mouse model and the intrabuccal route for CBD administration to determine the optimal dose at ...
Oluwadara Pelumi Omotayo   +4 more
wiley   +1 more source

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