Results 71 to 80 of about 10,227,551 (246)
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Hold-up and Sequential Specific Investments. [PDF]
We explore the hold-up problem when trading parties can make specific investments simultaneously or sequentially. As previously emphasized in the literature, sequencing of investments can allow some projects to proceed that would not be feasible with a ...
Wait, A., Smirnov, V.
core
Chemical Engineering Transactions, 2019 The characteristic flow patterns of the three-phase gas-floating particles-liquid system produced in a baffled agitated vessel with two high-speed impellers on the common shaft were experimentally determined.
Anna Kielbus-Rapala +2 more
doaj +1 more source
Advanced Engineering Materials, Volume 27, Issue 6, March 2025.ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur +5 more
wiley +1 more source
Cumulative Innovation, Sampling and the Hold-Up Problem [PDF]
With cumulative innovation and imperfect information about the value of innovations, intellectual property rights can result in hold-up and therefore it may be better not to have them. Extending the basic cumulative innovation model to include 'sampling'
Rufus Pollock
core +2 more sources
EFFECT OF PHYSICAL PROPERTIES ON HEAT TRANSFER AND FLOW REGIMES IN BUBBLE COLUMNS
Al-Qadisiyah Journal for Engineering Science, 2015 This work discusses the effect of superficial gas velocity and liquid properties (viscosity μ, surface tension σ, thermal conductivity k , density ρ , specific heat Cp ) on the heat transfer coefficient and gas holdup investigated in a bubble column ...
Balasim A. Abid +2 more
doaj
CHIMIA, 2009 Hydrogen chloride and sulphur dioxide are gaseous by-products of chloridization processes that employ thionyl chloride. Absorption would be a feasible method to clean the rich gas stream.
Daniel Mesitschek, Ennio Vanoli
doaj +1 more source
Advanced Engineering Materials, EarlyView.Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt +8 more
wiley +1 more source