Results 1 to 10 of about 44,737 (248)

Secretory expression of cyclohexanone monooxygenase by methylotrophic yeast for efficient omeprazole sulfide bio-oxidation

open access: yesBioresources and Bioprocessing, 2021
Prochiral pyrmetazole can be asymmetrically oxidized into (S)-omeprazole, a proton pump inhibitor that is used to treat gastroesophageal reflux, by an engineered cyclohexanone monooxygenase (CHMO Acineto -Mut) that has high stereoselectivity.
Ya-Jing Li   +6 more
doaj   +1 more source

Effects of cadmium sulfide nanoparticles on sulfate bioreduction and oxidative stress in Desulfovibrio desulfuricans

open access: yesBioresources and Bioprocessing, 2022
Highlight Efficiency of bioreduction of sulfate and biomass can be increased by CdS NPs. It is important for the EPS of RSB to improve the sulfate reduction efficiency. Utilization efficiency of extracellular electrons by RSB can be enhanced through EPS.
Guoqing Cheng   +6 more
doaj   +1 more source

De novo synthesis of nervonic acid and optimization of metabolic regulation by Yarrowia lipolytica

open access: yesBioresources and Bioprocessing, 2023
Nervonic acid, a natural fatty acid compound and also a core component of nerve fibers and nerve cells, has been widely used to prevent and treat related diseases of the brain nervous system.
Xin-Ru Zhao   +6 more
doaj   +1 more source

Expression of recombinant human Apolipoprotein A-IMilano in Nicotiana tabacum

open access: yesBioresources and Bioprocessing, 2023
Apolipoprotein A-IMilano (Apo A-IMilano) is a natural mutant of Apolipoprotein. It is currently the only protein that can clear arterial wall thrombus deposits and promptly alleviate acute myocardial ischemia.
Wei Zhao   +9 more
doaj   +1 more source

Identification of a prognostic ferroptosis-related lncRNA signature in the tumor microenvironment of lung adenocarcinoma

open access: yesCell Death Discovery, 2021
Ferroptosis is closely linked to various cancers, including lung adenocarcinoma (LUAD); however, the factors involved in the regulation of ferroptosis-related genes are not well established.
Yugang Guo   +8 more
doaj   +1 more source

Two strategies to improve the supply of PKS extender units for ansamitocin P-3 biosynthesis by CRISPR–Cas9

open access: yesBioresources and Bioprocessing, 2022
Ansamitocin P-3 (AP-3) produced by Actinosynnema pretiosum is a potent antitumor agent. However, lack of efficient genome editing tools greatly hinders the AP-3 overproduction in A. pretiosum.
Siyu Guo   +6 more
doaj   +1 more source

Enhancing mesenchymal stem cells cultivated on microcarriers in spinner flasks via impeller design optimization for aggregated suspensions

open access: yesBioresources and Bioprocessing, 2023
During the ex vivo expansion of umbilical cord-derived mesenchymal stem cells (hUCMSCs) in a stirred tank bioreactor, the formation of cell–microcarrier aggregates significantly affects cell proliferation and physiological activity, making it difficult ...
Botao Zhang   +6 more
doaj   +1 more source

Application of 8-parallel micro-bioreactor system with non-invasive optical pH and DO biosensor in high-throughput screening of l-lactic acid producing strain

open access: yesBioresources and Bioprocessing, 2018
Background Compared with shake flask, bioreactor offers a relatively stable and controllable extracellular environment for cell growth and metabolism.
Xiwei Tian   +8 more
doaj   +1 more source

Vitamin combination promotes ex vivo expansion of NK-92 cells by reprogramming glucose metabolism

open access: yesBioresources and Bioprocessing, 2022
Robust ex vivo expansion of NK-92 cells is essential for clinical immunotherapy. The vitamin B group is critical for the expansion and function of immune cells.
Yan Fu   +5 more
doaj   +1 more source

Efficient generation of male germ-like cells derived during co-culturing of adipose-derived mesenchymal stem cells with Sertoli cells under retinoic acid and testosterone induction

open access: yesStem Cell Research & Therapy, 2019
Background Adipose-derived mesenchymal stem cells (ADMSCs) are considered an efficient and important candidate for male infertility treatment because they contain pluripotent stem cells, which can differentiate into all cells from three germ layers ...
Yanxia Luo   +9 more
doaj   +1 more source

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