Results 21 to 30 of about 81,744 (305)

Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish

open access: yesNature Communications, 2018
In humans, caspase-5 is an LPS sensor that can induce gasdermin D cleavage and pyroptosis. Here, the authors show that zebrafish caspy2 is a functional homolog as it also senses cytosolic LPS to activate the noncanonical inflammasome and to protect ...
Dahai Yang   +13 more
doaj   +1 more source

Enhancing mesenchymal stem cells cultivated on microcarriers in spinner flasks via impeller design optimization for aggregated suspensions

open access: yesBioresources and Bioprocessing, 2023
During the ex vivo expansion of umbilical cord-derived mesenchymal stem cells (hUCMSCs) in a stirred tank bioreactor, the formation of cell–microcarrier aggregates significantly affects cell proliferation and physiological activity, making it difficult ...
Botao Zhang   +6 more
doaj   +1 more source

Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism

open access: yesBiotechnology for Biofuels, 2019
Background Acetate, an economical industrial chemical, which is also the precursor of acetyl-CoA, could serve as an alternative substrate for biomanufacturing.
Qin Xu   +9 more
doaj   +1 more source

Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation

open access: yesMicrobial Cell Factories, 2020
Background Glucoamylase is one of the most industrially applied enzymes, produced by Aspergillus species, like Aspergillus niger. Compared to the traditional ways of process optimization, the metabolic engineering strategies to improve glucoamylase ...
Weiqiang Cao   +6 more
doaj   +1 more source

Development and testing of a fully adaptable membrane bioreactor fouling model for a sidestream configuration system [PDF]

open access: yes, 2013
This article is available through the Brunel Open Access Publishing Fund. Copyright © 2013 MDPI AGA dead-end filtration model that includes the three main fouling mechanisms mentioned in Hermia (i.e., cake build-up, complete pore blocking, and pore ...
Paul, P, Parneet Paul
core   +1 more source

Mixomics analysis of Bacillus subtilis: effect of oxygen availability on riboflavin production

open access: yesMicrobial Cell Factories, 2017
Background Riboflavin, an intermediate of primary metabolism, is one kind of important food additive with high economic value. The microbial cell factory Bacillus subtilis has already been proven to possess significant importance for the food industry ...
Junlang Hu   +9 more
doaj   +1 more source

Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose

open access: yesBioresources and Bioprocessing, 2021
In this study, introduction of a viable cell sensor and electronic nose into ethanol fermentation was investigated, which could be used in real-time and on-line monitoring of the amount of living cells and product content, respectively.
Yao Feng   +7 more
doaj   +1 more source

A miniaturized bioreactor system for the evaluation of cell interaction with designed substrates in perfusion culture [PDF]

open access: yes, 2011
In tissue engineering, the chemical and topographical cues within three-dimensional (3D) scaffolds are normally tested using static cell cultures but applied directly to tissue cultures in perfusion bioreactors.
M. O. Riehle   +17 more
core   +1 more source

Dynamic response of Aspergillus niger to single pulses of glucose with high and low concentrations

open access: yesBioresources and Bioprocessing, 2019
Microorganisms generally encounter a fluctuating environment in their natural habitat and similar conditions also happen in large-scale bioreactors. In this work, the dynamic response of intracellular and extracellular metabolites of Aspergillus niger ...
Shuai Wang   +7 more
doaj   +1 more source

Role and variations of supernatant compounds in submerged membrane bioreactor fouling [PDF]

open access: yes, 2005
Many studies have been performed to analyze the influence of extracellular polymeric substances (EPS) in membrane fouling. Most of these works deal with the impact of solid contents in the fouling, and some of them have studied the role ofsupematant ...
Albasi, Claire   +3 more
core   +1 more source

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