Results 21 to 30 of about 96,256 (296)

Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition

Scientific Reports, 2018
Oxygen limitation is regarded as a useful strategy to improve enzyme production by mycelial fungus like Aspergillus niger. However, the intracellular metabolic response of A. niger to oxygen limitation is still obscure. To address this, the metabolism of
Hongzhong Lu, Weiqiang Cao, Xiaoyun Liu, Yufei Sui, Liming Ouyang, Jianye Xia, Mingzhi Huang, Yingping Zhuang, Siliang Zhang, Henk Noorman, Ju Chu   +10 more
doaj   +1 more source

Vitamin combination promotes ex vivo expansion of NK-92 cells by reprogramming glucose metabolism

Bioresources and Bioprocessing, 2022
Robust ex vivo expansion of NK-92 cells is essential for clinical immunotherapy. The vitamin B group is critical for the expansion and function of immune cells.
Yan Fu, Yuying Chen, Zhepei Xie, Huimin Huang, Wen-Song Tan, Haibo Cai   +5 more
doaj   +1 more source

Modelling of submerged membrane bioreactor: Conceptual study about link between activated slugde biokinetics, aeration and fouling process [PDF]

, 2008
A mathematical model was developed to simulate filtration process and aeration influence on Submerged Membrane Bioreactor (SMBR) in aerobic conditions.
Zarragoitia Gonzalez, Alain, Zarragoitia-González, Alain, Albasi, Claire, Schetrite, Sylvie, Jáuregui Haza, Ulises Javier, Alliet, Marion   +5 more
core   +1 more source

Peptide-Functionalized Electrospun Meshes for the Physiological Cultivation of Pulmonary Alveolar Capillary Barrier Models in a 3D-Printed Micro-Bioreactor

, 2023
In vitro environments that realize biomimetic scaffolds, cellular composition, physiological shear, and strain are integral to developing tissue models of organ-specific functions.
Daniel Felder (16490887), Matthias Wessling (1465381), Martin Möller (1377198), John Linkhorst (15928927), Puja Jain, Smriti Singh, Sebastian B. Rauer (16490884), Matthias Wessling, Martin Möller, Puja Jain (2538532), Smriti Singh (2290186), John Linkhorst, Daniel Felder, Sebastian B. Rauer   +13 more
core   +5 more sources

Enhancement of fatty acid degradation pathway promoted glucoamylase synthesis in Aspergillus niger

Microbial Cell Factories, 2022
Background Our recent multi-omics analyses of glucoamylase biosynthesis in Aspergillus niger (A. niger) suggested that lipid catabolism was significantly up-regulated during high-yield period under oxygen limitation.
Jie Qi, Xianzun Xiao, Liming Ouyang, Chenghan Yang, Yingping Zhuang, Lixin Zhang   +5 more
doaj   +1 more source

Bioreactor technology in cardiovascular tissue engineering

, 2022
S.29-37Cardiovascular tissue engineering is a fast evolving field of biomedical science and technology to manufacture viable blood vessels, heart valves, myocardial substitutes and vascularised complex tissues.
Hansmann, J., Mertsching, H.
core   +1 more source

Mixomics analysis of Bacillus subtilis: effect of oxygen availability on riboflavin production

Microbial Cell Factories, 2017
Background Riboflavin, an intermediate of primary metabolism, is one kind of important food additive with high economic value. The microbial cell factory Bacillus subtilis has already been proven to possess significant importance for the food industry ...
Junlang Hu, Pan Lei, Ali Mohsin, Xiaoyun Liu, Mingzhi Huang, Liang Li, Jianhua Hu, Haifeng Hang, Yingping Zhuang, Meijin Guo   +9 more
doaj   +1 more source

Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation

Microbial Cell Factories, 2020
Background Glucoamylase is one of the most industrially applied enzymes, produced by Aspergillus species, like Aspergillus niger. Compared to the traditional ways of process optimization, the metabolic engineering strategies to improve glucoamylase ...
Weiqiang Cao, Guan Wang, Hongzhong Lu, Liming Ouyang, Ju Chu, Yufei Sui, Yingping Zhuang   +6 more
doaj   +1 more source

Development and testing of a fully adaptable membrane bioreactor fouling model for a sidestream configuration system [PDF]

, 2013
This article is available through the Brunel Open Access Publishing Fund. Copyright © 2013 MDPI AGA dead-end filtration model that includes the three main fouling mechanisms mentioned in Hermia (i.e., cake build-up, complete pore blocking, and pore ...
Paul, P, Parneet Paul
core   +1 more source

A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications [PDF]

, 2023
The Quantum cell expansion system manufactured by Terumo-BCT is perhaps the most widely reported Good Manufacturing Practice–compliant bioreactor used for the expansion of adherent cell populations, both for research purposes and clinical cell–based ...
Rix, Larissa, Claire Mennan, Larissa Rix, Wright, Karina, Perry, Jade, Tian Lan, Mennan, Claire, Hulme, Charlotte H., McCarthy, Helen S., Helen S. McCarthy, Rebecca Davies, Davies, Rebecca, Jade Perry, Karina Wright, Charlotte H. Hulme, Lan, Tian   +15 more
core   +1 more source