Results 11 to 20 of about 44,737 (248)

Enhancement of fatty acid degradation pathway promoted glucoamylase synthesis in Aspergillus niger

Microbial Cell Factories, 2022
Background Our recent multi-omics analyses of glucoamylase biosynthesis in Aspergillus niger (A. niger) suggested that lipid catabolism was significantly up-regulated during high-yield period under oxygen limitation.
Jie Qi, Xianzun Xiao, Liming Ouyang, Chenghan Yang, Yingping Zhuang, Lixin Zhang   +5 more
doaj   +1 more source

Differentiation roadmap of embryonic Sertoli cells derived from mouse embryonic stem cells

Stem Cell Research & Therapy, 2019
Background Embryonic Sertoli cells (eSCs) play an important role in sex determination and in male gonad development which makes them a very useful cell type for therapeutic applications.
Chenze Xu, Ali Mohsin, Yanxia Luo, Lili Xie, Yan Peng, Qizheng Wang, Haifeng Hang, Yingping Zhuang, Meijin Guo   +8 more
doaj   +1 more source

Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish

Nature Communications, 2018
In humans, caspase-5 is an LPS sensor that can induce gasdermin D cleavage and pyroptosis. Here, the authors show that zebrafish caspy2 is a functional homolog as it also senses cytosolic LPS to activate the noncanonical inflammasome and to protect ...
Dahai Yang, Xin Zheng, Shouwen Chen, Zhuang Wang, Wenting Xu, Jinchao Tan, Tianjian Hu, Mingyu Hou, Wenhui Wang, Zhaoyan Gu, Qiyao Wang, Ruilin Zhang, Yuanxing Zhang, Qin Liu   +13 more
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Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition

Scientific Reports, 2018
Oxygen limitation is regarded as a useful strategy to improve enzyme production by mycelial fungus like Aspergillus niger. However, the intracellular metabolic response of A. niger to oxygen limitation is still obscure. To address this, the metabolism of
Hongzhong Lu, Weiqiang Cao, Xiaoyun Liu, Yufei Sui, Liming Ouyang, Jianye Xia, Mingzhi Huang, Yingping Zhuang, Siliang Zhang, Henk Noorman, Ju Chu   +10 more
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Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism

Biotechnology for Biofuels, 2019
Background Acetate, an economical industrial chemical, which is also the precursor of acetyl-CoA, could serve as an alternative substrate for biomanufacturing.
Qin Xu, Chenxiao Bai, Yiqi Liu, Lili Song, Lin Tian, Yunfeng Yan, Jinfeng Zhou, Xiangshan Zhou, Yuanxing Zhang, Menghao Cai   +9 more
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Mixomics analysis of Bacillus subtilis: effect of oxygen availability on riboflavin production

Microbial Cell Factories, 2017
Background Riboflavin, an intermediate of primary metabolism, is one kind of important food additive with high economic value. The microbial cell factory Bacillus subtilis has already been proven to possess significant importance for the food industry ...
Junlang Hu, Pan Lei, Ali Mohsin, Xiaoyun Liu, Mingzhi Huang, Liang Li, Jianhua Hu, Haifeng Hang, Yingping Zhuang, Meijin Guo   +9 more
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Iterative gene integration mediated by 26S rDNA and non-homologous end joining for the efficient production of lycopene in Yarrowia lipolytica

Bioresources and Bioprocessing, 2023
Because of its potent antioxidant effects, lycopene has been used in various industries including, but not limited to, food, medical, and cosmetic industries.
Zhen Luo, Jiang-Ting Shi, Xin-Liang Chen, Jun Chen, Feng Liu, Liu-Jing Wei, Qiang Hua   +6 more
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Dynamic response of Aspergillus niger to single pulses of glucose with high and low concentrations

Bioresources and Bioprocessing, 2019
Microorganisms generally encounter a fluctuating environment in their natural habitat and similar conditions also happen in large-scale bioreactors. In this work, the dynamic response of intracellular and extracellular metabolites of Aspergillus niger ...
Shuai Wang, Peng Liu, Wei Shu, Chao Li, Huan Li, Shanshan Liu, Jianye Xia, Henk Noorman   +7 more
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Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose

Bioresources and Bioprocessing, 2021
In this study, introduction of a viable cell sensor and electronic nose into ethanol fermentation was investigated, which could be used in real-time and on-line monitoring of the amount of living cells and product content, respectively.
Yao Feng, Xiwei Tian, Yang Chen, Zeyu Wang, Jianye Xia, Jiangchao Qian, Yingping Zhuang, Ju Chu   +7 more
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Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation

Microbial Cell Factories, 2020
Background Glucoamylase is one of the most industrially applied enzymes, produced by Aspergillus species, like Aspergillus niger. Compared to the traditional ways of process optimization, the metabolic engineering strategies to improve glucoamylase ...
Weiqiang Cao, Guan Wang, Hongzhong Lu, Liming Ouyang, Ju Chu, Yufei Sui, Yingping Zhuang   +6 more
doaj   +1 more source