Results 31 to 40 of about 2,507,328 (341)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Natural Gas Industry B, 2016 The Jurassic Shaximiao Fm gas reservoir in the Zhongjiang Gas Field, Sichuan Basin, is the main base of Sinopec Southwest Oil & Gas Company for gas reserves and production increase during the 12th Five-Year Plan.
Zhongping Li +5 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A First Mass Production of Gas Electron Multipliers [PDF]
, 2003 We report on the manufacture of a first batch of approximately 2,000 Gas Electron Multipliers (GEMs) using 3M's fully automated roll to roll flexible circuit production line. This process allows low-cost, reproducible fabrication of a high volume of GEMs
Aidala +15 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
THE ANALYSIS OF OIL WELLS CONSTRUCTION IN ABNORMAL CONDITIONS IN EASTERN SIBERIA OIL-FIELDS
Известия высших учебных заведений: Нефть и газ, 2016 The paper presents an analysis of oil wells construction at oil fields of Eastern Siberia. The petrophysical formation cross-section affecting the quality of oil wells construction is characterized. In addition, drilling and casing experience under those
V. A. Parfiryev +2 more
doaj +1 more source
Multi-level modelling of the hydrodynamics in gas phase polymerisation reactors [PDF]
, 2005 The gas-solid fluidised bed process is the most versatile process for the production of polyolefins, because it allows the production of polyolefins with a broad distribution of both the product density and molecular weight.
Bokkers, Gijsbertus Albert
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Key Technologies for the Design of Kilo-Ton Heavy-Duty Ultra-High Derrick Substructure
Shiyou jixieTo meet the demands of exploration and development of 10 000-meter ultradeep wells， research on key technologies for the design of kilo-ton heavy-duty ultra-high derrick substructure was conducted.
Hou Min +4 more
doaj +1 more source