Results 181 to 190 of about 512,062 (356)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Effect of an alginate-based antacid and simulated gastric acid on the surface roughness and color stability of CAD/CAM resin-based materials. [PDF]

BMC Oral Health
Hartavi DD, Cızıroğlu N, Sasany R, Babat MA, Mosaddad SA.   +4 more
europepmc   +1 more source

Case report: A pediatric case of repeated false-positive urea breath test for Helicobacter pylori without decreased gastric acid secretion. [PDF]

Front Med (Lausanne), 2023
Nishino M, Kakiuchi T, Fukuda K, Yoshiura M.   +3 more
europepmc   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Controlling gastric acid. [PDF]

BMJ, 1970
George Dickson, Crawford W. Jamieson
openaire   +3 more sources

Medicinal Plants in Food Supplements for Gastrointestinal Disorders: Critical Assessment of Health Claims on Gastric Acid Regulation. [PDF]

Nutrients
Teterovska R, Skotele RE, Maurina B, Sile I.   +3 more
europepmc   +1 more source

Gastric Acid-Responsive ROS Nanogenerators for Effective Treatment of Helicobacter pylori Infection without Disrupting Homeostasis of Intestinal Flora. [PDF]

Adv Sci (Weinh), 2023
Yu J, Guo Z, Yan J, Bu C, Peng C, Li C, Mao R, Zhang J, Wang Z, Chen S, Yao M, Xie Z, Yang C, Yang YY, Yuan P, Ding X.   +15 more
europepmc   +1 more source

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

Effect of Simulated Gastric Acid on Surface Characteristics and Color Stability of Hybrid CAD/CAM Materials. [PDF]

Polymers (Basel)
Yıldırım-Işık H, Büyükgöze-Dindar M.   +1 more
europepmc   +1 more source

Gastric acid challenge of lithium disilicate-reinforced glass-ceramics and zirconia-reinforced lithium silicate glass-ceramic after polishing and glazing-impact on surface properties. [PDF]

Clin Oral Investig, 2023
Hjerppe J, Shahramian K, Rosqvist E, Lassila LVJ, Peltonen J, Närhi TO.   +5 more
europepmc   +1 more source