Results 251 to 260 of about 5,895,661 (425)

Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair

open access: yesAdvanced Science, EarlyView.
CircGLIS3(2), a circRNA transiently upregulated in dermal fibroblasts during acute wound healing, is induced by IL‐1α and TGF‐β. Its RNA activates fibroblasts into matrix‐secreting cells, while its encoded protein enhances proliferation. The RNA stabilizes PCOLCE, and the protein interacts with BTF3, collectively accelerating wound repair. Abstract The
Guanglin Niu   +20 more
wiley   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang   +9 more
wiley   +1 more source

Night-time gastric acid suppression by tegoprazan compared to vonoprazan or esomeprazole. [PDF]

open access: yesBr J Clin Pharmacol, 2022
Yang E   +9 more
europepmc   +1 more source

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

open access: yesAdvanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng   +27 more
wiley   +1 more source

Effects of Gastric Acid Secretion Inhibitors for Ventilator-Associated Pneumonia. [PDF]

open access: yesFront Pharmacol, 2022
Li F   +8 more
europepmc   +1 more source

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