Results 121 to 130 of about 9,492 (194)

Multiple Sampling Capsule Robot for Studying Gut Microbiome

open access: yesAdvanced Intelligent Systems, EarlyView.
A multiple sampling capsule robot (MSCR) is developed for longitudinal gut microbiome analysis. Employing electromagnetic field control, the MSCR can locomote actively, precisely align the selected channel, and collect up to six microbiome samples with minimal cross‐contamination.
Sanghyeon Park   +3 more
wiley   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo   +3 more
wiley   +1 more source

Electrical Tissue Adhesives for Strain‐Insensitive In‐situ Biosensing

open access: yesAdvanced Intelligent Systems, EarlyView.
Interfacing rigid, non‐stretchable biosensors with soft, deformable tissues presents significant challenges due to their fundamentally contradictory properties. This work reports an electrical tissue adhesive featuring an entangled adhesive polymer network interpenetrated with a sacrificial dissipative polymer network that can rapidly and robustly ...
Tsz Hung Wong   +10 more
wiley   +1 more source

Multi‐Module Micro/Nanorobots for Biomedical and Environmental Remediation Applications

open access: yesAdvanced Intelligent Systems, EarlyView.
Multi‐module microrobots (MNRs) have overcome the limitations of single‐module systems by integrating components such as propeller, actuator, manipulator, and imaging modalities. They show promise in biomedical applications, such as targeted drug delivery and tissue repair, as well as in environmental remediation, including pollutant removal.
Bairong Zhu   +4 more
wiley   +1 more source

Hierarchical Superposition Framework Reveals the Complex Effects of Natural Medicine Formulas

open access: yesAdvanced Intelligent Systems, EarlyView.
A novel hierarchical superposition pharmacological model incorporates the principle of hierarchical structures from physics to simulate the spatiotemporal dynamics of drug combinations, to elucidate the universal law underlying drug combination effects. By modeling cross‐level causal transmission and attenuation, it advances beyond traditional additive
Weifeng Liang   +3 more
wiley   +1 more source

Functional Characterization of a Genetic Variant in the 5′ UTR of APC 1B Promoter in a Familial Adenomatous Polyposis Family

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic germline variants in the APC gene result in familial adenomatous polyposis (FAP) which can escalate into colon cancer. Standard clinical testing failed to identify pathogenic variants in a 4‐generation FAP family. We identified and assessed co‐segregation of a 5′ untranslated region (UTR) variant, NM_001127511.3 (APC) c.‐40G>A ...
Brendon Young   +9 more
wiley   +1 more source

Gut Microbiome Pilot Study of Patients With CHARGE Syndrome and Sibling Controls

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Difficulties with feeding and digestion are common in individuals with CHARGE syndrome. Animal models with CHD7 gene variants demonstrate abnormal gut innovation and dysmotility. Our pilot study evaluated whether individuals with CHARGE syndrome have differences in their gut microbiome compared to unaffected siblings.
Emily R. Chedrawe   +5 more
wiley   +1 more source

Truncating Variants in RREB1 Cause a Novel RASopathy Syndrome of Congenital Heart Disease, Genitourinary Malformations, and Developmental Delay

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The interstitial 6p microdeletion syndrome is characterized by dysmorphic facies and structural heart, kidney, brain, and musculoskeletal differences. RREB1 haploinsufficiency and consequent abnormal RAS‐MAPK pathway signaling have been proposed as a driver of the disease phenotype; however, apart from a single case report, the phenotype of ...
Alanna Strong   +16 more
wiley   +1 more source

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