Results 231 to 240 of about 5,337,491 (425)
Advanced Science, EarlyView.A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang +16 more
wiley +1 more source
Allium Vegetables Intake and Digestive System Cancer Risk: A Study Based on Mendelian Randomization, Network Pharmacology and Molecular Docking [PDF]
arXivBackground: Allium vegetables (garlic and onion) are one of the flavorings in people's daily diets. Observational studies suggest that intake of allium vegetables may be correlated with a lower incidence of digestive system cancers. However, the existence of a causal relationship is still controversial due to confounding factors and reverse causation ...
arxiv
SIGNIFICANT ASSOCIATION BETWEEN THE ANGIOTENSIN-CONVERTING ENZYME INSERTION/DELETION POLYMORPHISM AND GASTRIC CANCER IN ARDABIL PROVINCE,IRAN [PDF]
Background: Gastric cancer as the 3rd most common malignancy in Iran, accounts for 50% of all GI cancers who cause 55% of all cancer-related deaths in Iran. The rates of gastric cancer reported from Ardabil province, Iran, are among the highest in the
اخوان, هما +5 more
core
Polysaccharides and a Glycidamin in the Tissue of Gastric Cancer
, 1949 Kiyota Oh-Uti
openalex +2 more sources
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun +10 more
wiley +1 more source
Advanced Science, EarlyView.RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong +13 more
wiley +1 more source
An Integrated AI-Enabled System Using One Class Twin Cross Learning (OCT-X) for Early Gastric Cancer Detection [PDF]
arXivEarly detection of gastric cancer, a leading cause of cancer-related mortality worldwide, remains hampered by the limitations of current diagnostic technologies, leading to high rates of misdiagnosis and missed diagnoses. To address these challenges, we propose an integrated system that synergizes advanced hardware and software technologies to balance ...
arxiv
Studies on the Specific Antigens of Human Gastric Cancer. I
, 1956 K. Kobayashi
openalex +2 more sources
Advanced Science, EarlyView.By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley +1 more source
A Comparative Analysis of Image Descriptors for Histopathological Classification of Gastric Cancer [PDF]
arXivGastric cancer ranks as the fifth most common and fourth most lethal cancer globally, with a dismal 5-year survival rate of approximately 20%. Despite extensive research on its pathobiology, the prognostic predictability remains inadequate, compounded by pathologists' high workload and potential diagnostic errors.
arxiv