Results 81 to 90 of about 454,943 (311)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Role for the Vacuolating Cytotoxin, VacA, in Colonization and Helicobacter pylori-Induced Metaplasia in the Stomach [PDF]

, 2014
Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gas-tric adenocarcinoma. To our knowledge, we are the first to determine effects of different polymorphic forms of VacA on inflammation and ...
Ingram, R J M, Atherton, J C, Zaitoun, Abed, Amilon, Karin, Winter, Jody, Atherton, John, Croxall, N J, Zaitoun, A A M, Croxall, Nicola, Robinson, Karen, Robinson, K, Letley, D P, Amilon, K R, Kaye, Phillip, Ingram, Richard, Kaye, P V, Rhead, J L, Cook, K W, Rhead, Joanne, Letley, Darren, Winter, JA, Cook, Katherine   +21 more
core   +1 more source

Experiences of multidisciplinary gastric cancer treatment at the National Cancer Center, Korea [PDF]

Korean Journal of Clinical Oncology, 2013
Multidisciplinary treatment (MDT) is considered to be beneficial for patients undergoing complex treatments for cancer. The efforts of MDT led to the initiation of nowadays well known trials in gastroesophageal cancer treatment.
Daniel Reim, Bang Wool Eom, Young-Woo Kim   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Avelumab in Gastric Cancer

Immunotherapy, 2019
Gastric cancer (GC) is the fifth most common malignancy and the third cause of cancer-related deaths worldwide. Currently, surgery and chemotherapy remain the main therapeutic options and the prognosis of the disease is still poor in the metastatic setting.
Roviello G., D'Angelo A., Generali D., Pittacolo M., Ganzinelli M., Iezzi G., De Manzini N., Sobhani N.   +7 more
openaire   +6 more sources

Who Can Perform Adjuvant Chemotherapy Treatment for Gastric Cancer? A Multicenter Retrospective Overview of the Current Status in Korea [PDF]

, 2018
Purpose: To investigate the current status of adjuvant chemotherapy (AC) regimens in Korea and the difference in efficacy of AC administered by surgical and medical oncologists in patients with stage II or III gastric cancers.Materials and Methods: We ...
김민규
core   +1 more source

Differences in patient-reported symptoms following radical gastrectomy: a propensity score-matched cohort study

Frontiers in Oncology
BackgroundSurgery is not only the mainstay of treatment for gastric cancer but also the key to improving postoperative quality of life for patients. Patient-reported symptoms following radical gastrectomy tend to be diverse and descriptive.
Yuan Xie, Li Li, Rui Xu, Qiong Gu, Shuo-meng Xiao, Hong-Li Ma   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Incidence and survival of oesophageal and gastric cancer in England between 1998 and 2007, a population-based study. [PDF]

, 2012
BACKGROUND: Major changes in the incidence of oesophageal and gastric cancers have been reported internationally. This study describes recent trends in incidence and survival of subgroups of oesophageal and gastric cancer in England between 1998 and 2007
Hardwick, Richard H, Blazeby, Jane M, Jane M Blazeby, Elizabeth A Davies, Davies, Elizabeth A; id_orcid, Victoria H Coupland, Møller, Henrik; id_orcid, Coupland, Victoria H, Henrik Møller, Karen M Linklater, Møller, Henrik, Richard H Hardwick, Linklater, Karen M, Michael A Mendall, William Allum, Allum, William, Davies, Elizabeth A, Mendall, Michael A   +17 more
core   +1 more source

Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response

Nature Communications
Cancer-associated fibroblasts (CAF) play a crucial role in tumor progression and immune regulation. However, the functional heterogeneity of CAFs remains unclear. Here, we identify antigen-presenting CAFs (apCAF), characterized by high MHC II expression,
Junquan Song, Rongyuan Wei, Chenchen Liu, Zhenxiong Zhao, Xuanjun Liu, Yanong Wang, Fenglin Liu, Xiaowen Liu   +7 more
doaj   +1 more source