Results 51 to 60 of about 785,687 (214)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Inhibition of Glutamine Uptake Improves the Efficacy of Cetuximab on Gastric Cancer

Integrative Cancer Therapies, 2021
Treatment for advanced gastric cancer is challenging. Epidermal growth factor receptor (EGFR) contributes to the proliferation and development of gastric cancer (GC), and its overexpression is associated with unfavorable prognosis in GC.
Huanrong Ma PhD, Jingjing Wu Bachelor, Minyu Zhou PhD, Jianhua Wu PhD, Zhenzhen Wu PhD, Li Lin PhD, Na Huang PhD, Wangjun Liao PhD, Li Sun PhD   +8 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

LIHNCS - Lugol's iodine in head and neck cancer surgery : a multicentre, randomised controlled trial assessing the effectiveness of Lugol’s iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in situ at mucosal resection margins of oral and oropharyngeal squamous cell carcinoma : study protocol for a randomised controlled trial [PDF]

, 2013
Background: Oral cavity and oropharynx cancer are increasing in incidence worldwide but survival outcomes have not significantly improved over the last three decades. The presence of dysplasia or carcinoma in situ at surgical margins following resection
McMahon, Jeremy, Mehanna, Hisham M., McConkey, Christopher C., Hisham Mehanna, Sutton, David N., Dunn, Janet, Cymerman, James A, McCaul, James A, Sutton, David N, Shaw, Richard, James A McCaul, Dunn, Janet A., McCaul, James A., Jeremy McMahon, David N Sutton, Cymerman, James A., Hislop, Stuart, McConkey, Chris, James A Cymerman, Stuart Hislop, Richard Shaw, Mehanna, Hisham; id_orcid, Chris McConkey, Janet Dunn   +23 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Relation of gallbladder function and Helicobacter pylori infection to gastric mucosa inflammation in patients with symptomatic cholecystolithiasis [PDF]

, 2006
Background. Inflammatory alterations of the gastric mucosa are commonly caused by Helicobacter pylori (Hp) infection in patients with symptomatic gallstone disease.
Burkhard Göke, Göke, Burkhard, Panos Stathopoulos, Fritz W. Spelsberg, Jüngst, Dieter, Diebold, Joachim, Stathopoulos, Panos, Lasse Kolligs, Joachim Diebold, Zündt, Benedikta, Benedikta Zündt, Dieter Jüngst, Spelsberg, Fritz W., Kolligs, Lasse   +13 more
core   +1 more source

Down-Regulated MAC30 Expression Inhibits Proliferation and Mobility of Human Gastric Cancer Cells

Cellular Physiology and Biochemistry, 2014
Background: Gastric cancer is one of the most common cancers in the world. MAC30/Transmembrane protein 97 (TMEM97) is aberrantly up-regulated in many human carcinoma cells.
Xiao-Yan Xu, Li-Juan Zhang, Yan-Qiu Yu, Xiao-Tong Zhang, Wan-jing Huang, Xiao-Cui Nie, Guo-Qing Song   +6 more
doaj   +1 more source

Lysosomal-associated protein transmembrane 4 Beta-35 overexpression is a novel independent prognostic marker for gastric carcinoma. [PDF]

PLoS ONE, 2015
The purpose of this work was to analyze the relationships between the expression status of Lysosomal-associated protein transmembrane-4 beta 35 (LAPTM4B-35) in cancerous tissues and clinicopathological characteristics and prognosis of the patients with ...
Luying Liu, Xuefang Xu, Lili Jing, Gengyin Zhou, Zhang Cao, Yanchun Han, Rouli Zhou   +6 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

New Surgical Approach for Gastric Bezoar: "Hybrid Access Surgery" Combined Intragastric and Single Port Surgery [PDF]

, 2011
Regarding the removal of a gastric bezoar, laparoscopic surgery was performed and it was shown that the laparoscopic approach is safe and feasible. However, the laparoscopic method has the risk of intraabdominal contamination, when the gastric bezoar is ...
손태일, 형우진, 박경호, 노성훈   +3 more
core   +1 more source