Results 231 to 240 of about 51,482 (245)

GLP-1 receptor agonists and delayed gastric emptying: implications for invasive cardiac interventions and surgery. [PDF]

Cardiovasc Endocrinol Metab
Shankar A, Sharma A, Vinas A, Chilton RJ.   +3 more
europepmc   +1 more source

A Combined Modeling Approach to Predict the Effect of Gastric Emptying Delay on the Pharmacokinetics of Small Molecules

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Dulaglutide, a long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is approved for improving glycemic control and reducing cardiovascular risks in patients with type 2 diabetes mellitus (T2DM). This research investigates the effect of dulaglutide on gastric emptying and its impact on the pharmacokinetics (PK) of orally administered ...
Maria M. Posada, Karen B. Schneck, Bridget L. Morse, Luc R. A. Rougee, Lai San Tham, Jessica F. Rehmel, Brian Thompson, Stephen D. Stamatis, Stephen D. Hall, Gemma L. Dickinson   +9 more
wiley   +1 more source

Delayed Gastric Emptying Correlates With Decreased Post-prandial Motility in Children: A Single-center Retrospective Review. [PDF]

J Neurogastroenterol Motil
Sanchez RE, Reichard E, Bobbey A, Puri NB, Lu PL, Yacob D, Di Lorenzo C, Williams K, Vaz KKH.   +8 more
europepmc   +1 more source

An Open‐Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT To establish bioequivalence (BE) of a generic test formulation with respect to a reference listed drug, it is necessary to demonstrate a comparable rate and extent to which active ingredients reach the site of action. To decrease unnecessary human testing and simulate scenarios involving specific populations or challenges with recruitment or ...
Abdullah Hamadeh, Moriah Pellowe, Pierre Chelle, Cindy Hoi Ting Yeung, Julian Otalvaro, Walter Yamada, Jay Bartroff, Alona Kryshchenko, André Dallmann, Juri Solodenko, Jörg Lippert, Eleftheria Tsakalozou, Michael Neely, Andrea Edginton   +13 more
wiley   +1 more source

<i>Lacticaseibacillus paracasei</i> HP7 Improves Gastric Emptying by Modulating Digestive Factors in a Loperamide-Induced Functional Dyspepsia Mouse Model. [PDF]

J Microbiol Biotechnol
Jeong JW, Lee D, Kim H, Gwon H, Lee K, Kim JY, Shim JJ, Lee JH.   +7 more
europepmc   +1 more source

A Population Pharmacokinetic Approach to Understand the Effect of Efavirenz on CYP3A Activity in Healthy Volunteers Using Midazolam as a Probe

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Efavirenz induces and inhibits multiple drug‐metabolizing enzymes, contributing to significant drug–drug interactions. This study quantified the impact of multiple doses of efavirenz on CYP3A activity via midazolam metabolism using a population pharmacokinetic approach.
Kimberly S. Collins, Blessed W. Aruldhas, Ingrid F. Metzger, Jessica B. L. Lu, Michael A. Heathman, Sara K. Quinney, Zeruesenay Desta   +6 more
wiley   +1 more source

Prophylactic endoscopic pylorus dilatation prior to esophagectomy for esophageal cancer to prevent delayed gastric emptying, study protocol for a placebo-controlled randomized trial (PROPPER trial). [PDF]

Trials
Mann C, Berlth F, Lozanovski VJ, Passalacqua M, Hadzijusufovic E, Uzun E, Capovilla G, Valmasoni M, Lang H, Grimminger PP.   +9 more
europepmc   +1 more source

Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide.

J Clin Endocrinol Metab
Jalleh RJ, Plummer MP, Marathe CS, Umapathysivam MM, Quast DR, Rayner CK, Rayner CK, Jones KL, Wu T, Horowitz M, Horowitz M, Nauck MA.   +11 more
europepmc   +1 more source

Effects of Tegoprazan, Potassium-Competitive Acid Blocker, on the Gastric Emptying and Postprandial Symptoms in Healthy Humans. [PDF]

Dig Dis Sci
Lim HS, Yoon HJ, Jung HK, Hong JT, Yoo MY, Jeong ES.   +5 more
europepmc   +1 more source

Management of gestational diabetes mellitus via nutritional interventions: The relevance of gastric emptying. [PDF]

World J Diabetes
Huang WK, Jalleh RJ, Rayner CK, Wu TZ.
europepmc   +1 more source