Results 151 to 160 of about 960,379 (379)

The effect of electric current on HCl secretion by isolated frog gastric mucosa [PDF]

, 1948
Eleanor Crane, R. E. Davies, Norah M. Longmuir   +2 more
openalex   +1 more source

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, EarlyView.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

A Rare Etiology of Abnormally Large Gastric Folds: Menetrier’s Disease

Case Reports in Gastrointestinal Medicine, 2019
Menetrier’s disease (MD) is described as hypertrophied giant gastric folds causing hypoproteinemia due to protein losing gastropathy and is associated with higher risk of gastric adenocarcinoma.
Muhammad Umar Kamal, Hassan Tariq, Vaniza Mehak, Sara Azam, Kishore Kumar, Masooma Niazi, Anil Dev   +6 more
doaj   +1 more source

Exosomal CCT6A Secreted by Cancer‐Associated Fibroblasts Interacts with β‐Catenin to Enhance Chemoresistance and Tumorigenesis in Gastric Cancer

Advanced Science, EarlyView.
Here, it is revealed that CAF‐secreted exosomal CCT6A enhances stemness, chemoresistance, and glycolysis in GC via the β‐catenin/c‐Myc/DDIT4‐TXNIP axis. Furthermore, CCT6P1, a pseudogene of CCT6A, is identified as upregulating CCT6A by competitively binding miR‐922, while c‐Myc transcriptionally activates both CCT6P1 and CCT6A.
Hui Sun, Tianqi Zhang, Xiaoyan Zhang, Yingxue Liu, Xu Wang, Xin Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Xiaoyu Wang, Wenfeng Wang, Weiqi Sheng, Mi‐die Xu   +15 more
wiley   +1 more source

DISTRIBUTION OF ESTERASE IN GASTRIC MUCOSA [PDF]

, 1954
William L. Doyle
openalex   +1 more source

Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment

Advanced Science, EarlyView.
A novel melanin‐based therapeutic composed of ultrasmall polydopamine nanodots is employed as an efficient oral formulation for the targeted treatment of inflammatory bowel disease. The potential therapeutic mechanism of polydopamine nanodots mainly involves the elimination of excessive oxidative stress, the reduction of ROS‐mediated proinflammatory ...
Zhen Ding, Xingfu Bao, Ying Zhao, Lin Bai, Jinming Zhang, Chengjing Xu, Tianyan Chen, Shuang Dai, Yufu Liu, Min Hu, Meng Qin, Zhen Liu   +11 more
wiley   +1 more source

Polyphenol‐Based Functional Materials: Structural Insights, Composite Strategies, and Biomedical Applications

Advanced Science, EarlyView.
This schematic representation illustrates the interaction mechanisms between polyphenolic compounds and various materials (metals, proteins, polysaccharides, alkaloids, etc.). And explains the potential clinical application value of these materials (nanoparticles, coatings, films, capsules, and hydrogels constructed using polyphenols) in the fields of ...
Songwen Xue, Wen Tan, Shuifang Mao, Haibo Pan, Xingqian Ye, Natthawuddhi Donlao, Jinhu Tian   +6 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Carbon‐Coated Probiotics Restore Intestinal Homeostasis to Promote Damage Repair in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Carbon‐coated Lactobacillus rhamnosus GG (C dots@LGG) enhances the antioxidant effects of LGG and safeguards the probiotics to target the inflamed colon. This reduces inflammation and oxidative damage, repairs the intestinal barrier, regulates the microbiota, and alleviates colitis.
Xue Chen, Haiyan Guo, Yuhan Li, Qiaowen Lin, Hua Liu, Liwen Hong, Lei Wang, Jie Zhong, Dalong Ni, Zhengting Wang   +9 more
wiley   +1 more source