Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren+16 more
wiley +1 more source
THE GASTRIC MUCOSA IN DELIRIUM TREMENS [PDF]
In the experience of Dr. E. R. Le Count, coroner's physician in Chicago, petechial hemorrhages in the stomach lining are among the most constant lesions found in the bodies of persons dying during the acute delirium of chronic alcoholism. This condition has been considered an acute alcoholic gastritis, but in the absence of any microscopic examination ...
openaire +3 more sources
Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins [PDF]
Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. H. suis colonizes the
Adamczyk, Barbara+11 more
core +1 more source
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed+8 more
wiley +1 more source
Dental Biofilm, a reservoir for Helicobacter Pylori in patients with chronic gastritis
Objectives: To determine the prevalence of helicobacter pylori in dental biofilm in patients with chronic gastritis in the gastroenterology service of Hospital María Helper.
Israel Armando Guerra Cuyutupac
doaj +1 more source
Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injury [PDF]
Recent data of study H2S in gastrointestinal tract has proven its potent cytoprotection on mucosal defense among acid-related diseases in the gut. The aim was to evaluate the effects of H2S-releasing aspirin derivative (ATB-340) on esophageal and gastric
O. S. Zayachkivska1+6 more
doaj +1 more source
Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats [PDF]
ObjectiveTo observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats.MethodsAll rats were randomly divided into normal control group, cirrhosis and treatment group. Thioacetamide was used to establish rat model
Cai, Chun-Jiang+7 more
core +1 more source
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
Remodeling of the residual gastric mucosa after roux-en-y gastric bypass or vertical sleeve gastrectomy in diet-induced obese rats. [PDF]
Whereas the remodeling of intestinal mucosa after bariatric surgeries has been the matter of numerous studies to our knowledge, very few reported on the remodeling of the residual gastric mucosa.
Konstantinos Arapis+11 more
doaj +1 more source
On Sensation to Pain in the Gastric Mucosa [PDF]
n ...
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