Results 201 to 210 of about 3,517,895 (261)

First‐In‐Human Study of Mirogabalin (BM2216) Sustained‐Release Tablets: Safety, Tolerability, Pharmacokinetics, Food Effect and Dose Proportionality With Comparison to Mirogabalin Besylate in Healthy Participants

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To characterise the pharmacokinetics (PKs) and safety of BM2216 sustained‐release (SR) tablets after single‐dose oral administration under fasted/fed conditions in healthy participants, assess the effect of food and dose proportionality, and compare the single and multiple‐dose PK of BM2216 SR tablets with mirogabalin besylate tablets to ...
Peiyang Song   +6 more
wiley   +1 more source

Postelectroacupuncture Fecal Microbiota Transplantation (post‐EA FMT) Regulates Gastrointestinal Hormones in Functional Dyspepsia Rats Is Associated With Modulation of the Intestinal Microbiota‐Bile Acid Metabolic Pathway

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Electroacupuncture (EA) reshapes intestinal flora; whether post‐EA fecal microbiota transplantation (post‐EA FMT) regulates gastrointestinal hormones via the gut microbiota–bile acid (BA) pathway remains unclear. Methods Sham EA (SEA) served as control. Gastrointestinal hormones/motility were assessed post‐EA.
Yong‐Li Han   +6 more
wiley   +1 more source

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways

open access: yesJournal of Periodontal Research, EarlyView.
This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru   +2 more
wiley   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

open access: yesJournal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi   +10 more
wiley   +1 more source

N-Glycoproteomics Sample Preparation Using Commercially Available Cellulose Magnetic Particles. [PDF]

open access: yesMol Cell Proteomics
Hanzawa K   +4 more
europepmc   +1 more source

Connect or detach: A transformative experience for medical students in end‐of‐life care

open access: yesMedical Education, Volume 59, Issue 4, Page 395-408, April 2025.
Abstract Context At the beginning of clinical practice, medical students face complex end‐of‐life (EoL) decisions, such as limiting life‐sustaining therapies, which may precipitate emotionally charged moral dilemmas. Previous research shows these dilemmas may cause identity dissonance and impact students' personal and professional development.
Diego Lima Ribeiro   +3 more
wiley   +1 more source

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