Results 71 to 80 of about 1,473,631 (241)

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Successful treatment of nonocclusive mesenteric ischemia in a reconstructed jejunum after esophagectomy and remnant gastric tube resection: a case report

Surgical Case Reports, 2023
Background Nonocclusive mesenteric ischemia (NOMI), an ischemic bowel disease without a disruption of the mesenteric blood flow or strangulation of the mesentery or intestine, may cause a lethal clinical course.
Koichi Okamoto, Hiroto Saito, Mari Shimada, Takahisa Yamaguchi, Toshikatsu Tsuji, Hideki Moriyama, Jun Kinoshita, Keishi Nakamura, Itasu Ninomiya, Hiroyuki Takamura, Noriyuki Inaki   +10 more
doaj   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

A novel laparoscopic assisted mediastinal dissection with gastric tube inversion technique for gastric tube cancer reconstructed through a retrosternal route

Annals of Gastroenterological Surgery, 2021
A median sternotomy is often performed in patients with gastric tube cancer reconstructed through the retrosternal route; however, this procedure is invasive and has the risk of severe infectious complications.
Tetsuya Abe, Yoshihisa Numata, Eiji Higaki, Takahiro Hosoi, Yasuhiro Shimizu   +4 more
doaj   +1 more source

Radical Resection of the Third Portion of the Duodenum for Secondary Aortoduodenal Fistula

Annals of Gastroenterological Surgery, EarlyView.
Secondary aortoduodenal fistula most commonly involves the third portion of the duodenum and requires definitive management of both vascular and gastrointestinal components. We demonstrate a step‐by‐step technique for radical duodenal resection and reconstruction performed in structured collaboration with cardiovascular surgeons.
Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Tatsuichiro Seto, Yuji Soejima   +4 more
wiley   +1 more source

Aortoesophageal fistula treated using one-stage total reconstruction: a case report from a high-volume center

Journal of Cardiothoracic Surgery, 2023
Background Aortoesophageal fistula (AEF) is a rare but typically life-threatening condition. Although several treatment strategies exist, including conservative treatment with intraluminal stent graft and open thoracic aortic replacement, the overall ...
Yi-Ping Lee, Kensuke Ozaki, Susumu Oshima, Tomohiro Hirokami   +3 more
doaj   +1 more source

Comparative cranial biomechanics reveal macroevolutionary trends in theropod dinosaurs, with emphasis on Tyrannosauroidea

The Anatomical Record, EarlyView.
Abstract Tyrannosaurus is viewed as a model organism in vertebrate paleontology, with numerous studies analyzing its feeding biomechanics. Nonetheless, the evolution of this feeding performance has been under‐addressed in Tyrannosauroidea, especially in basal tyrannosauroids. Here we used muscle‐force reconstruction and finite element analysis (FEA) to
Evan Johnson‐Ransom, Paul Gignac, Daniel E. Barta, Ryan N. Felice, Eric Snively   +4 more
wiley   +1 more source

Land birds on atolls: diversity, origin, and function

Biological Reviews, EarlyView.
ABSTRACT Oceanic islands are global hotspots of avian biodiversity and endemism. Their isolation and distinct environmental conditions have uniquely shaped the evolutionary trajectories of island birds, while, in turn, land bird communities have become critical providers of ecological functions to island ecosystems.
Sebastian Steibl, Alex S. Wegmann, Nick D. Holmes, Caitlin E. Andrews, Gérard Rocamora, Simon Ducatez, James C. Russell   +6 more
wiley   +1 more source

Thoracoscopic retrosternal gastric conduit resection in the supine position for gastric tube cancer [PDF]

, 2019
Introduction: Recent advances in the treatment for esophageal cancer have improved the prognosis after esophagectomy, but they have led to an increased incidence of gastric tube cancer.
Satoshi Suzuki, Kanaji, Shingo, Nakamura, Tetsu, Ishida, Sonoko, Ikeda, Taro, Yamamoto, Masashi, Yamashita, Kimihiro, Yasufumi Koterazawa, Yoshiko Matsuda, Horie, Kazumasa, Takeru Matsuda, Yuta Yamazaki, Sakamoto, Hiroki, Matsuda, Takeru, Kazumasa Horie, Tetsu Nakamura, Taro Oshikiri, Yamazaki, Yuta, Koterazawa, Yasufumi, Sonoko Ishida, Kimihiro Yamashita, Shimizu, Masaki, Yu Kitamura, Oshikiri, Taro, Kitamura, Yu, Hiroki Sakamoto, Yoshihiro Kakeji, Matsuda, Yoshiko, Taro Ikeda, Masaki Shimizu, Kakeji, Yoshihiro, Masashi Yamamoto, Shingo Kanaji, Suzuki, Satoshi   +33 more
core   +1 more source

Anion‐Selective Channels Formed by Synthetic 13‐Mer Chimeric α ‐Peptide‐Oligourea Foldamers

Chemistry – A European Journal, EarlyView.
Synthetic 13‐mer α‐peptide‐oligourea chimeric foldamers self‐assemble into supramolecular ion channels, demonstrating high ion transport activity with distinct anion selectivity in lipid membranes. This study supports the design of bioinspired functional foldamer‐based channels for synthetic ion transport applications.
Chiranjit Dutta, Dandan Su, Pannaga Krishnamurthy, Zhaoxing Li, Jianwei Li, Morgane Pasco, Min Luo, Mihail Barboiu, Gilles Guichard, R. Manjunatha Kini, Prakash Kumar   +10 more
wiley   +1 more source