Results 31 to 40 of about 4,150 (157)

E‐selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor‐prognosis signature in colorectal cancer

Molecular Oncology, Volume 19, Issue 3, Page 635-658, March 2025.
Screening colorectal tumors for glycoproteins linked to disease progression has revealed several potential therapeutic targets. The secretin receptor (SCTR), identified as a marker of poor prognosis and metastasis in colorectal cancer, has been shown to be a key carrier of N‐glycans with sialylated Lewis antigens. These cancer‐specific glycoproteoforms
Sofia Cotton, Dylan Ferreira, Marta Relvas‐Santos, Andreia Brandão, Luís Pedro Afonso, Andreia Miranda, Eduardo Ferreira, Beatriz Santos, Martina Gonçalves, Paula Lopes, Lúcio Lara Santos, André M. N. Silva, José Alexandre Ferreira   +12 more
wiley   +1 more source

Interferon-alpha-2a is a potent inhibitor of hormone secretion by cultured human pituitary adenomas [PDF]

, 1999
Interferon-alpha (IFN alpha) may exert direct inhibitory effects on cell proliferation and on the production of different peptide hormones. We investigated the effect of IFN alpha on hormone production by 15 GH-secreting ...
Herder, W.W. (Wouter) de, Hofland, L.J. (Leo), Koetsveld, P.M. (Peter) van, Lamberts, S.W.J. (Steven), Uitterlinden, P. (Piet), Waaijers, M. (Marlijn), Zuijderwijk, J. (Joke)   +6 more
core  

Endoscopic ultrasound‐guided tissue acquisition allows a reliable proliferation assessment of small (≤20 mm) pancreatic neuroendocrine tumors

Annals of Gastroenterological Surgery, Volume 9, Issue 2, Page 339-346, March 2025.
Distribution of Ki‐67 proliferation indices in EUS‐TA versus surgical histological assessment. Abstract Aim Evidence regarding the reliability of endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) for assessing histological proliferation and WHO grading of small (≤20 mm) pancreatic neuroendocrine tumors (PanNETs) is limited.
Yoshihide Nanno, Hirochika Toyama, Kazuyuki Nagai, Dongha Lee, Yuichiro Uchida, Jun Ishida, Takeshi Takahara, Ippei Matsumoto, Etsuro Hatano, Takumi Fukumoto   +9 more
wiley   +1 more source

Considerations concerning a tailored, individualized therapeutic management of patients with (neuro)endocrine tumours of the gastrointestinal tract a [PDF]

, 2004
Endocrine tumours of the gastrointestinal tract and pancreas may present at different disease stages with either hormonal or hormone-related symptoms/syndromes, or without hormonal symptoms. They may occur either sporadically or as part
Eijck, C.H.J. (Casper) van, Herder, W.W. (Wouter) de, Krenning, E.P. (Eric), Lamberts, S.W.J. (Steven)   +3 more
core  

Surgical Experiences of Functioning Neuroendocrine Neoplasm of the Pancreas [PDF]

, 2006
We present our surgical experiences with functioning neuroendocrine neoplasms of the pancreas to define its natural history, and to suggest its proper management.
Akerstrom, Anderson, Azimuddin, Byong Ro Kim, Chang Moo Kang, Delcore, Gagner, Grant, Heitz, Howard, Jin Sub Choi, Kim, Kyung Sik Kim, Lairmore, Matthews, Melvin, Phan, Se Ho Park, Thompson, Woo Jung Lee, Yu   +20 more
core   +2 more sources

Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms

International Journal of Cancer, Volume 156, Issue 5, Page 980-992, 1 March 2025.
What's New? Epigenetic regulation has been suggested to play a major role in the pathogenesis of gastroenteropancreatic neuroendocrine tumours, but the underlying mechanisms remain poorly understood. Here, the authors show in two independent cohorts that the calcium‐sensing receptor (CaSR) is down‐regulated in gastroenteropancreatic neuroendocrine ...
Katherine A. English, Michelle Goldsworthy, Brittannie Willis, Kreepa G. Kooblall, Shweta Birla, Andreas Selberherr, Mark Stevenson, Omair A. Shariq, Ann L. Oberg, Tony Wang, James Carmichael, Konstantinos Mavrommatis, Laure Escoubet, Rajesh V. Thakker, Sarah A. Howles, Kate E. Lines   +15 more
wiley   +1 more source

Incidence and Prognostic Implications of Lymphovascular Invasion in Node‐Negative Pancreatic Neuroendocrine Tumors: Results From the US Neuroendocrine Study Group

Journal of Surgical Oncology, Volume 131, Issue 3, Page 465-472, March 2025.
ABSTRACT Background Despite the well‐known prognostic role of lymph node metastasis (LNM) in pNETs, less is known about the importance of lymphovascular invasion (LVI) among patients with these tumors. Methods Patients undergoing pancreatectomy for pNET between 2002 and 2020 were identified in the US Neuroendocrine Tumor Study Group database.
Kota Sahara, Diamantis I. Tsilimigras, Yuki Homma, Jun Kawashima, Shishir K. Maithel, Flavio Rocha, Sharon Weber, Ryan Fields, Kamran Idrees, George A. Poultsides, Cliff Cho, Itaru Endo, Timothy M. Pawlik   +12 more
wiley   +1 more source

A 41-Year-Old Man with Two Types of Metachronous Peptic Ulcer Complication due to Zollinger-Ellison Syndrome—Regression of Pancreatic Primary after Chemoembolization of Hepatic Metastases: A Case Report [PDF]

, 2011
Introduction. Gastrinoma should be suspected when the peptic ulcer(s) is postbulbar, multiple, refractory, or recurrent, or ulcer is associated with nephrolithiasis, hypocalcaemia, or erosive esophagitis. The majority of gastrinomas are malignant.
Ghadir, Mohammad Reza, Sarkeshikian, Seyed Saeid   +1 more
core   +3 more sources

Current status of peptide receptor radionuclide therapy in grade 1 and 2 gastroenteropancreatic neuroendocrine tumours

Journal of Neuroendocrinology, Volume 37, Issue 3, March 2025.
Abstract Peptide receptor radionuclide therapy (PRRT) using [177Lu‐DOTA0,Tyr3]octreotate (177Lu‐DOTATATE) represents an established treatment modality for somatostatin receptor‐positive, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumours (GEP NET) of grade 1 or 2.
Jelka Kuiper, Eline Zoetelief, Tessa Brabander, Wouter W. de Herder, Johannes Hofland   +4 more
wiley   +1 more source

Nuclear medicine in endocrine tumours [PDF]

, 2011
C
Peremans, Kathelijne, Van De Wiele, Christophe   +1 more
core   +2 more sources