Results 91 to 100 of about 4,691 (257)
Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model [PDF]
International Journal of Ophthalmology, 2017 AIM: To investigate the neuroprotective effect of gastrodin on retinal ganglion cells (RGCs) in an acute ocular hypertension (AOH) rat model and to identify its possible mechanism.
Jia-Wei Wang +3 more
doaj +1 more source
The cultivation, bioactive components and pharmacological effects of Armillaria mellea [PDF]
, 2012 Armillaria mellea, a symbiotic fungus in the underground tubers of Chinese medicinal orchid Gastrodia elata, is one of the main biological active components and pharmaceutical effects of its host gastrodia.
Gao, LW, Li, WY, Wang, JW, Zhao, YL
core +2 more sources
The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 12, December 2025.ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SIONFH) is a debilitating orthopedic condition. This study investigated the mechanism of Tanshinone I (TsI) in SIONFH modulating apoptosis in SIONFH via the PI3K/AKT/mTOR pathway. A SIONFH rat model was treated with TsI and a PI3K activator. Bone mineral density (BMD), bone volume/total volume
Qing Su, Jia Chen
wiley +1 more source
E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy
MedComm, Volume 6, Issue 12, December 2025.E3 ligases function as critical regulators of cellular protein degradation, and their dysregulation is a core pathogenic mechanism in a wide array of human diseases, including cancer, cardiovascular conditions, neurodegenerative disorders, and autoimmune diseases.
Haochen Wang +6 more
wiley +1 more source
Gastrodin ameliorates cognitive dysfunction in diabetes by inhibiting PAK2 phosphorylation
Aging, 2023 Diabetes is associated with higher prevalence of cognitive dysfunction, while the underlying mechanism is still elusive. In this study, we aim to explore the potential mechanism of diabetes-induced cognitive dysfunction and assess the therapeutic effects of Gastrodin on cognitive dysfunction. Diabetes was induced by a single injection of streptozotocin.
Mu, Zhi-Hao +15 more
openaire +2 more sources
GePIF4 Increases the Multi-Flower/Capsule-Bearing Traits and Gastrodin Biosynthesis in <i>Gastrodia elata</i>. [PDF]
Plants (Basel)The degeneration of germplasm is a key factor limiting the yield and quality of Gastrodia elata Blume. Sexual reproduction is a primary method to address this degeneration, while the number of flowers and capsules is directly related to sexual ...
Xu Y +6 more
europepmc +2 more sources
Brain and Behavior, Volume 15, Issue 11, November 2025.This retrospective real‐world study of 190 Chinese patients with refractory focal epilepsy demonstrated that adjunctive PER achieved sustained responder rates (∼66%) and seizure freedom (∼27%) over 12 months, with an acceptable safety profile. Male gender, higher doses, and late add‐on predicted better outcomes, while adults experienced fewer adverse ...
Tong Yi +6 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.Our study elucidates PKA‐mediated generation of a 30 kD N‐terminal truncation of NLRP3 (miniNLRP3) in a serine protease dependent manner, which could potentiate the activation of the NLRP3 inflammasome under high glucose conditions via promoting the dissociation of HK2 from mitochondria.
Hengchang Zhang +9 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 10, October 2025.This research provides novel insights into the role of the gut‐brain axis in the pathogenesis of AD and highlights Crocin's potential as a therapeutic candidate for improving both cognitive function and pathological outcomes in AD. We believe these findings have significant implications for understanding the interplay between gut microbiota and ...
Zhiyan Zou +6 more
wiley +1 more source
Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China
British Journal of Pharmacology, Volume 182, Issue 20, Page 4741-4760, October 2025.Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang +5 more
wiley +1 more source