Results 101 to 110 of about 4,691 (257)

Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration

open access: yesAdvanced Science, Volume 12, Issue 33, September 4, 2025.
This review highlights recent advanced in immunomodulatory biomaterials for bone repair, focusing on design strategies, immune interactions, and clinical potential. Abstract The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive ...
Jianan Li   +11 more
wiley   +1 more source

Novel Strategies Using Total Gastrodin and Gastrodigenin, or Total Gastrodigenin for Quality Control of Gastrodia elata

open access: yesMolecules, 2018
Gastrodia elata Blume (G. elata), a traditional Chinese medicine, is widely used for treatment of various neuro dysfunctions. However, its quality control is still limited to the determination of gastrodin.
Chunlan Tang   +4 more
doaj   +1 more source

Mitochondrial Quality Control in Health and Disease

open access: yesMedComm, Volume 6, Issue 8, August 2025.
Mitochondrial quality control (MQC) maintains cellular homeostasis by coordinating various processes such as fission, fusion, mitophagy, and mitochondria‐regulated cell death. Dysregulation of these mechanisms plays a key role in the development of many human diseases.
Lin Ye, Xinzhi Fu, Qi Li
wiley   +1 more source

Medicinal plant cultivation for sustainable use and commercialisation of high-value crops [PDF]

open access: yes, 2022
Many traditional healing systems are based on natural biological resources, and there is a general shift in most parts of the world towards natural medicine, with direct implications on the demand and supply of medicinal plants.
Amoo, Stephen O.   +6 more
core   +1 more source

Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Microglia interact with oxidative stress, reactive astrocytes, neuronal damage, neuroinflammation, synaptic dysfunction, mitochondrial dysfunction, epigenetic modifications, and blood–brain barrier disruption, playing a critical role in the pathophysiology of perioperative neurocognitive disorders (PND).
Xizhen Liu, Anke Zhang
wiley   +1 more source

Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer

open access: yesActa Pharmaceutica Sinica B, 2014
Borneol is a traditional Chinese medicine that can promote drug absorption from the gastrointestinal tract and distribution to the brain. However, stomach irritation may occur when high doses of borneol are used.
Zheng Cai   +7 more
doaj   +1 more source

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

open access: yesMedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu   +7 more
wiley   +1 more source

Plantamajoside Promotes NGF/TrkA Pathway to Inhibit Neuronal Apoptosis and Improve Diabetic Peripheral Neuropathy

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 8, April 2025.
ABSTRACT The symptoms caused by diabetic peripheral neuropathy (DPN) have severely impacted patients' quality of life. While plantamajoside (PMS) exhibits neuroprotective properties, its efficacy and molecular mechanisms against DPN are unexplored.
Qingshan Hai   +11 more
wiley   +1 more source

PREDICTION OF ANTI-PARKINSON POTENTIAL OF PHYTOCONSTITUENTS USING PREDICTION OF ACTIVITY SPECTRA OF SUBSTANCES SOFTWARE [PDF]

open access: yes, 2018
Objective: Neurodegenerative disorders are group of diseased conditions in which there is loss of neuron cells occur. The main objective of this study to find/search out the phytochemical with the help of prediction of activity spectra of substances ...
Anand, Abhinav   +4 more
core   +1 more source

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