Results 201 to 210 of about 4,691 (257)

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

Chemistry & Biodiversity
Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin ...
Naoual El menyiy, Youssef Elouafy, Rania Moubachir, Rhizlan Abdnim, T. Benali, Douae Taha, Asaad Khalid, Ashraf N. Abdalla, Siddiqa M A Hamza, Salma Elhadi Ibrahim, Mohamed El-Shazly, Gokhan Zengin, A. Bouyahya   +12 more
semanticscholar   +3 more sources

Gastrodin destabilizes survivin and overcomes pemetrexed resistance

Cellular Signalling, 2023
Survivin is a bifunctional protein that plays crucial roles in tumorigenesis. In the present study, we discovered that the natural product gastrodin suppressed the cell viability and colony formation of non-small cell lung cancer (NSCLC) cell lines A549, HCC827, and H460 in a dose-dependent manner.
Jinzhuang, Liao, Xiang, Qing, Gaoyan, Deng, Yeqing, Xiao, Yaqian, Fu, Shuangze, Han, Xiaoying, Li, Yu, Gan, Wei, Li   +8 more
openaire   +2 more sources

Gastrodin Pretreatment Alleviates Renal Ischemia-Reperfusion Injury

Urologia Internationalis, 2022
<b><i>Introduction:</i></b> This study aimed to investigate the possible effect of gastrodin in renal ischemia-reperfusion injury (IRI) and the mechanisms. <b><i>Methods:</i></b> Forty-eight male Sprague Dawley rats were randomly divided into 3 groups: sham-operated group, saline-treated IRI group, and ...
Yi, Zheng, Nan, Zhang, Fuding, Bai
openaire   +2 more sources

Gastrodin protects against cardiac hypertrophy and fibrosis

Molecular and Cellular Biochemistry, 2011
Phenolic glucoside gastrodin (Gas), which is a main component extracted from the Chinese herbs Gastrodia elata Bl, is a well-known natural calcium antagonist with antioxidant and anti-inflammatory functions. It has long been used clinically for treatment of cardiovascular and cerebrovascular diseases.
Chunming, Shu, Changgui, Chen, Da-Ping, Zhang, Haipeng, Guo, Heng, Zhou, Jing, Zong, Zhouyan, Bian, Xuan, Dong, Jia, Dai, Yan, Zhang, Qizhu, Tang   +10 more
openaire   +2 more sources

Comparative pharmacokinetics of gastrodin in rats after intragastric administration of free gastrodin, parishin and Gastrodia elata extract

Journal of Ethnopharmacology, 2015
Gastrodia elata Blume, a traditional Chinese herb, was widely used against convulsant, vertigo, paralysis, epilepsy, tetanus, asthma and immune dysfunctions. Gastrodin is one of the major bioactive components of G. elata and it is known for its anticonvulsive, anti-inflammatory, antiepileptic and neuroprotective effects.An ultra high performance liquid
Chunlan, Tang, Li, Wang, Xinxin, Liu, Mengchun, Cheng, Yang, Qu, Hongbin, Xiao   +5 more
openaire   +2 more sources

De novo biosynthesis of Gastrodin in Escherichia coli

Metabolic Engineering, 2016
Gastrodin, a phenolic glycoside, is the key ingredient of Gastrodia elata, a notable herbal plant that has been used to treat various conditions in oriental countries for centuries. Gastrodin is extensively used clinically for its sedative, hypnotic, anticonvulsive and neuroprotective properties in China.
Yanfen, Bai, Hua, Yin, Huiping, Bi, Yibin, Zhuang, Tao, Liu, Yanhe, Ma   +5 more
openaire   +2 more sources

Gastrodin Attenuates Cognitive Deficits Induced by 3,3′-Iminodipropionitrile

Neurochemical Research, 2016
3,3'-Iminodipropionitrile (IDPN), one of the nitrile derivatives, can induce persistent neurotoxicity, and therefore cause dyskinesia and cognitive impairments. Gastrodin, a main bioactive ingredient of Gastrodia elata Blume, is shown to greatly improve cognitive function.
Xiaona, Wang, Peng, Li, Jingsheng, Liu, Xunbo, Jin, Lianjun, Li, Dong, Zhang, Peng, Sun   +6 more
openaire   +2 more sources

Gastrodin exerts perioperative myocardial protection by improving mitophagy through the PINK1/Parkin pathway to reduce myocardial ischemia-reperfusion injury.

Phytomedicine
BACKGROUND Although blood flow is restored after treatment of myocardial infarction (MI), myocardial ischemia and reperfusion (I/R) can cause cardiac injury, which is a leading cause of heart failure.
Lu Chen, Yong Lv, Huiliang Wu, Yanting Wang, Zhen Xu, Guoyang Liu, Yuyao He, Xia Li, Jie Liu, Yiqi Feng, Yunxiao Bai, Wanli Xie, Quanjun Zhou, Qingping Wu   +13 more
semanticscholar   +1 more source

Distribution and metabolism of gastrodin in rat brain

Journal of Pharmaceutical and Biomedical Analysis, 2008
Gastrodin is the major and bioactive component in Tianma (Gastrodia elata Bl.) and has sedative, anticonvulsive and neuroprotective effects. Since little is known about its neuropharmacokinetics and brain metabolism, this study was undertaken to investigate the kinetic inter-relationship of gastrodin in rat plasma, cerebrospinal fluid (CSF) and brain ...
Qiao, Wang, Guoshen, Chen, Su, Zeng
openaire   +2 more sources

Gastrodin alleviates rat chondrocyte senescence and mitochondrial dysfunction through Sirt3

International Immunopharmacology, 2023
Several researchers have focused on understanding the pathogenesis and treatment strategies for osteoarthritis (OA). Gastrodin (GAS) is a potential anti-inflammatory agent. In this study, we constructed an in vitro OA chondrocyte model by treating chondrocytes with IL-1β.
Yubiao Zhang, Wenyi Jin, Junwen Chen, Sixing Wei, WenXiang Cai, YuJian Zhong, Yan Zhou, Hao Peng   +7 more
openaire   +2 more sources