Results 211 to 220 of about 4,691 (257)

Gastrodin alleviates mitochondrial dysfunction by regulating SIRT3-mediated TFAM acetylation in vascular dementia.

Phytomedicine
BACKGROUND Mitochondrial dysfunction is key to the pathogenesis of vascular dementia (VaD). Sirtuin-3 (SIRT3), an essential member of the sirtuins family, has been proven to be a critical sirtuin in regulating mitochondrial function.
Yong-xin Chen, Hong Yang, Da-song Wang, Ting-ting Chen, Xiao-lan Qi, Ling Tao, Yan Chen, Xiang-chun Shen   +7 more
semanticscholar   +1 more source

Gastrodin Ameliorates Tau Pathology and BBB Dysfunction in 3xTg‐AD Transgenic Mice by Regulating the ADRA1/NF‐κB/NLRP3 Pathway to Reduce Neuroinflammation

Phytotherapy Research
Background and aim: Gastrodin, an active compound derived from the traditional Chinese herbal medicine Gastrodia, demonstrates a variety of pharmacological effects, particularly in the enhancement of neural functions.
Bo Li, Li Wang, Yan Xiao, Yang Wang, Yuanshang Wang, Yaqian Peng, Anni Zhang, Zhi Tang, Xiaolan Qi   +8 more
semanticscholar   +1 more source

Protective Effects of Gastrodin Against Autophagy‐Mediated Astrocyte Death

Phytotherapy Research, 2015
Gastrodin is an active ingredient derived from the rhizome of Gastrodia elata. This compound is usually used to treat convulsive illness, dizziness, vertigo, and headache. This study aimed to investigate the effect of gastrodin on the autophagy of glial cells exposed to lipopolysaccharides (LPS, 1 µg/mL).
Xin-shang, Wang, Zhen, Tian, Nan, Zhang, Jing, Han, Hong-liang, Guo, Ming-gao, Zhao, Shui-bing, Liu   +6 more
openaire   +2 more sources

The Pharmacological Effects of Gastrodin and the Progress in the Treatment of Neurological Disorders.

The American Journal of Chinese Medicine
Gastrodia elata Blume, a traditional medicinal herb primarily used in Asian countries such as China, has long been valued for treating headaches, dizziness, spasms, epilepsy, strokes, forgetfulness, and other ailments.
Han Guo, Dongmei Cheng, Cong Zhang, Fang Xue   +3 more
semanticscholar   +1 more source

Neuroprotective effects of gastrodin against bisphenol A induced-ADHD-like symptoms in rats

Drug and chemical toxicology (New York, N.Y. 1978)
Gastrodin (GAS) is a potent pharmaceutical compound extracted from the dried roots of a Chinese medicinal herb, Gastrodia elata Blume. It has been used as a neuroprotective treatment for a range of neurological disorders.
Mohd Anas Saifi, Huma Khan, Mehjbeen Javed, Shahzad Ahmad, Zuber Khan, A. Mangla, Garima Jindal, Suhel Parvez, Nidhi B. Agarwal, Sheikh Raisuddin   +9 more
semanticscholar   +1 more source

Antimicrobial gastrodin derivatives isolated from Bacopa procumbens

Phytochemistry Letters, 2019
Abstract The bioassay-guided fractionation of the hydroalcoholic extract from aerial parts of Bacopa procumbens (Mill.) Greenm., allowed to isolate the known phenolic compound arbutin (1) as well as three new gastrodin derivatives which were denominated procumgastrodin A, procumgastrodin B and procumgastrodin C.
Manasés González-Cortazar, Valentín López-Gayou, Jaime Tortoriello, Blanca E. Domínguez-Mendoza, Ada M. Ríos-Cortes, Raúl Delgado-Macuil, Elías E. Hernández-Beteta, Ever A. Blé-González, Alejandro Zamilpa   +8 more
openaire   +1 more source

Gastrodin attenuates rheumatoid arthritis by targeting KAT8 to inhibit the lactylation of H3K9

Frontiers in Pharmacology
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and joint destruction, with limited therapeutic options.
Yufang Dai, Shunshun Wang, Jiayi Luo, Huiming Yu, Qianqian Du, Shuwan Hou, Minfu Liu, Shan Jiang, Huajiao Xu, Siyi Ye, Muhammad Farrukh Nisar, Haiyan Chen, Jiaqin Wu   +12 more
semanticscholar   +1 more source

Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice.

Phytomedicine, 2023
BACKGROUND Regulating the microglial phenotype is an attractive strategy for treating diseases of the central nervous system such as depression and anxiety. Gastrodin can quickly cross the blood-brain barrier and mitigate microglia-mediated inflammation,
Jinqiang Zhang, Liang-Jun Li, Qin Liu, Zhihuang Zhao, Dapeng Su, Cheng-hong Xiao, Ting Jin, Li Chen, Chun-Qiang Xu, Zili You, Tao Zhou   +10 more
semanticscholar   +1 more source

Engineering Yarrowia lipolytica for Enhanced Gastrodin Production via High‐Throughput Screening and Transcriptomics‐Guided Optimization

Biotechnology and Bioengineering
Gastrodin, the principal bioactive component of the renowned herb Gastrodia elata, is extensively utilized in medicinal drugs and nutraceuticals. This study seeks to enhance microbial production of gastrodin through high‐throughput screening (HTS) and ...
Mengchen Hu, Yijin He, Yifan Ma, Na Wu, Zhongwen Gan, Jinhan Fu, Zhiliang Yang, Tianqiong Shi, Xiaoman Sun, Yang Gu, Peng Xu   +10 more
semanticscholar   +1 more source

Rapid HPLC determination of gastrodin in Gastrodiae Rhizoma

Journal of the Korean Society for Applied Biological Chemistry, 2015
Gastrodin is a major biologically active ingredient in members of the genus Gastrodia. For this reason, there are many reports on the quantification of gastrodin in Gastrodiae Rhizoma (GR) and in GR-containing herbal preparations. HPLC, HPLC–MS, and TLC are the major approaches for gastrodin quantification; however, they usually require complicated pre-
Ju-Gyeong Lee, Sung-Ok Moon, Se-Yong Kim, Eun-Ju Yang, Ju-Sik Min, Ju-Hee An, Eun-A Choi, Kwang-Hyeon Liu, Eun Ji Park, Hwa-Dong Lee, Kyung-Sik Song   +10 more
openaire   +1 more source