Results 221 to 230 of about 4,691 (257)

Neuroprotective activity of different monosaccharide‐modified gastrodin analogs

Journal of the Chinese Chemical Society, 2020
AbstractGastrodin is a very important and well‐known bioactive glycoside compound in Chinese medicine. It is also known as a drug with neuroprotective function. Here, a practical diversified synthesis of a series of gastrodin analogs was reported, which involved four‐step procedures consisting of bromination, oxidation, etherification, and reduction ...
Kun‐Lun Xu, Lan Yu
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Simultaneous determination of gastrodin and its metabolite by HPLC

Biomedical Chromatography, 1987
AbstractA rapid and specific HPLC method for the simultaneous determination of gastrodin and its metabolite gastrodigenin (p‐hydroxybenzyl alcohol) in rat plasma, bile, liver, urine and faeces is described. The separation was achieved by using a reversed phase column (YWG‐C18) eluted with methanol‐water (2.5:97.5 v/v).
K X, Liu, G Z, Han, Y L, Chang, C Y, Su, N Y, Tang, Y R, Chen   +5 more
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Small Intestinal Submucosa Hydrogel Loaded With Gastrodin for the Repair of Achilles Tendinopathy.

Small
Achilles tendinopathy (AT) is an injury caused by overuse of the Achilles tendon or sudden force on the Achilles tendon, with a considerable inflammatory infiltrate.
Xiqian Zhang, Mei Li, Xufeng Mao, Zheyu Yao, Weilai Zhu, Zheyang Yuan, Xiang Gao, Senghao Pan, Yijun Zhang, Jiyuan Zhao, Haijiao Mao   +10 more
semanticscholar   +1 more source

GASTRODIN PROTECTS AGAINST SEPSIS-ASSOCIATED ENCEPHALOPATHY BY SUPPRESSING FERROPTOSIS

Shock
ABSTRACT Background: Sepsis-associated encephalopathy (SAE) represents a severe complication of sepsis, substantially elevating both mortality and healthcare costs for patients. Gastrodin (GAS), a principal bioactive constituent of Gastrodia elata Blume, is neuroprotective in various neurological disorders ...
Yunfei Xu, Jing Chen, Lin Zhou, Yao Zhao, Nina He, Qing Xu, Jie Zhao, Ying Liu   +7 more
openaire   +2 more sources

Network pharmacology-based analysis of Gastrodin’s molecular mechanisms in rectal cancer

New Medicine
Background: Rectal cancer is a major global health challenge, and the pharmacological mechanisms of natural compounds for its treatment remain unclear.

semanticscholar   +1 more source

Bibliometric analysis of gastrodin

New Medicine
This study aims to delineate the research trends of gastrodin (GAS) and provide insights for future research. Relevant literature was first screened from the Web of Science Core Collection on GAS. Then, the research trend was analyzed using VOSviewer 1.6.20, Excel, and other online platforms.
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[Synthesis of gastrodin by microbial transformation].

Yao xue xue bao = Acta pharmaceutica Sinica, 2008
To synthesize gastrodin via biotransformation of microorganism using p-hydroxybenzaldehyde as substrate.Using resting cell techniques with TLC and HPLC analysis, a strain of Rhizopus chinensis Staito AS3. 1165 which has the capability of biotransforming p-hydroxybenzaldehyde into gastrodin was screened from 50 strains of microorganisms.
Hong-li, Zhu, Ji-rong, Song, Jian-xin, Huang, Jia, Zhang, Zhen-Yu, Ma, Ming-yan, Yang   +5 more
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Gastrodin ameliorates diabetic nephropathy by activating the AMPK/Nrf2 pathway

Journal of Molecular Histology
Diabetic nephropathy (DN) is a leading cause of end-stage kidney failure, contributing to elevated morbidity and mortality rates in individuals with diabetes. Despite its potential renoprotective effects, the molecular mechanism by which gastrodin (GSTD) impacts DN remains unclear.
Shuqin, Zhao, Qingyun, Pan, Xiaolin, Lin, Xian, Li, Li, Qu   +4 more
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Gastrodin attenuates neuroinflammation in DOI‐induce Tourette syndrome in rats

Journal of Biochemical and Molecular Toxicology, 2019
AbstractObjectiveTourette syndrome (TS) is a chronic neuropsychiatric disorder. Its clinical manifestations are involuntary and recurrent muscle twitch, resulting in motor twitch and occurrence twitch. Traditional Chinese medicine has obvious advantages in treating TS. The aim of this study was to investigate the effects and mechanism of gastrodin on 1‐
Hongyan Long, Chunyan Wang, Jie Ruan, Mengjiao Zhang, Yaruo Huang   +4 more
openaire   +2 more sources

Research on the mechanism of gastrodin in the treatment of liver cancer based on network pharmacology

New Discovery
Objective: Liver cancer remains a major cause of cancer mortality, with rising incidence worldwide. Gastrodin, a bioactive compound from Gastrodia elata, has shown anti-cancer potential.
Yu-Ying Zhou
semanticscholar   +1 more source